Antagonistic Effects of Suramin Against the Venom of the Iranian Snake Echis carinatus in Mice

Iranian Journal of Veterinary Science and Technology

مقاله 2، دوره 2، شماره 1، آذر 2010، صفحه 9-16   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v2i1.3943

نویسندگان

Behrooz Fathi^{* 1}؛ Fatemh Amani¹؛ Atena Jami al ahmadi¹؛ Abbase Zare²

¹Ferdowsi University of Mashhad

²Razi Vaccine and Serum Research Institute

چکیده

Echis carinatus (Saw-scale viper) is one of the most venomous snakes in Asia and some
parts of the Africa with deadly hemotoxic venom. It has been reported that suramin, an antitrypansomiasis
drug, can inhibits the toxic effects of some snake venoms. This study was
conducted to evaluate the antagonistic effects of suramin against the venom of the Iranian
snake Echis carinatus.
Adult albino mice weighing 35±5g were divided into nine groups (A1, A2, B1, B2, B3, C1,
C2, D and E) of 6-10 mice. Groups A1 and A2 (protocol A), which received the venom at 7 and
13 mg/kg, succumbed after 169±32 min and 53±16 min, respectively. Groups B1, B2 and B3
(protocol B) were treated with different doses of suramin 15 min after injection of venom.
The results show that suramin significantly delayed time to death in groups B1, B2 and B3
compared with groups A1 and A2 (P

کلیدواژه‌ها

suramin؛ Echis Carinatus؛ venom؛ antivenom؛ antagonist

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