Tert-butylhydroquinone (TBHQ) improves antioxidant status in rat tissues following chronic diazinon intoxication

Iranian Journal of Veterinary Science and Technology

مقاله 5، دوره 6، شماره 2، فروردین 2014، صفحه 42-52   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v6i2.39503

نویسندگان

saman Sargazi؛ Amir Moghadam Jafari؛ Mohammad Heydarpour^*

Ferdowsi University of Mashhad

چکیده

Considering that the involvement of oxidative stress has been implicated in the toxicity of organophosphate insecticides, the objective of the present study was to investigate antioxidants and oxidative stress markers in the liver and kidney of Wistar rats treated with chronic doses of diazinon. In addition, the effect of Tert-butylhydroquinone (TBHQ), a food-additive antioxidant, on attenuation of diazinon-induced oxidative stress was evaluated. 28 rats were randomly assigned to 1 of 4 treatment groups: diazinon (10 mg/kg BW, once a day; n=7), TBHQ (0.028 g/kg of diet, once a day; n=7), TBHQ + diazinon (diazinon; 10 mg/kg BW, once a day + TBHQ; 0.028 g/kg of diet, once a day; n=7) and control (corn oil, as vehicle of diazinon and TBHQ, n=7). TBHQ, diazinon and corn oil were given to rats orally via gavage for 7 weeks. Total thiol groups, ferric reducing antioxidant power (FRAP) and malondialdehyde (MDA) levels in liver and kidney tissues were investigated at the end of 7th week. Treatment with diazinon significantly increased MDA level, as a marker of lipid peroxidation, in the kidney (p

کلیدواژه‌ها

diazinon؛ oxidative stress, TBHQ؛ Rat

مراجع

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