The Role of Mesenchymal Stem Cells in Skin Wound Healing

Journal of Cell and Molecular Research

مقاله 2، دوره 7، شماره 2 - شماره پیاپی 14، اسفند 2015، صفحه 70-75   

نوع مقاله: Review / Mini-Review

شناسه دیجیتال (DOI): 10.22067/jcmr.v7i2.51937

نویسندگان

Tahereh Sanjari؛ Toktam Hajjar؛ Madjid Momeni-Moghaddam^*

Hakim Sabzevari University, Sabzevar, Iran

چکیده

Mesenchymal stem cells (MSCs) could differentiate into various types of tissues. These cells serve as a backup for the regeneration and repair of tissues or cells after injury. A skin wound is defined as an injury to the skin that needs to be restored. All types of cells in skin especially mesenchymal stem cells play important role in wound healing process. In particular, paracrine signaling of MSC regulates the cellular responses at the wound site leading to reduction of inflammation, stimulation of angiogenesis and induction of cell migration and proliferation. Because of these abilities, MSCs are one of the most common stem cells for cell therapy in wound healing. This review focuses on the role of MSCs on wound healing process. In addition, major phases of wound repair and challenges of cell therapy are discussed.

کلیدواژه‌ها

Mesenchymal Stem Cells؛ Wound healing؛ inflammation؛ Angiogenesis

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