Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock

Iranian Journal of Veterinary Science and Technology

مقاله 4، دوره 10، شماره 2 - شماره پیاپی 19، شهریور 2018، صفحه 37-42   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v2i10.73882

نویسندگان

Reza Azargoun¹؛ Reza Avizeh^{* 2}؛ Alireza Ghadiri¹؛ Hadi Imani Rastabi¹؛ Mahdi Pourmahdi Boroujeni¹؛ Mohammad Razi Jalali¹

¹shahid chamran university

²Shahid Chamran university

چکیده

This study sought to assess the levels of cardiac troponin I, as a resuscitation end point, along with oxygen delivery (DO2) and oxygen consumption (VO2) during resuscitation of dogs with experimental hemorrhagic shock using lactated Ringer’s solution or 6% hydroxyethyl starch. After induction of anesthesia (control measurements), hemorrhagic shock was induced by rapid removal of blood to achieve a mean arterial pressure (MAP) of 40 to 50 mmHg within 30 minutes and then maintained in hypovolemic situation for additional 30 minutes (second and third stages of measurements). Afterward, the dogs were randomly assigned to two groups which received 20 ml/kg lactated Ringer’s solution or 5 ml/kg Hydroxyethyl starch, in four consecutive 15 minutes intervals (forth stage of measurements). One hour after the last resuscitation step, final measurements were performed. Hemorrhagic shock caused marked elevation in the levels of cTnI and reduction in DO2 and VO2 (p < 0.05). Following resuscitation, a significant reduction was observed in the levels of cTnI and VO2 but a significant elevation was seen in DO2 levels (p < 0.05), without significant differences between the groups (p > 0.05). The results of this study proved that cTnI can be evaluated for better monitoring during fluid therapy in hemorrhagic shock, as a novel resuscitation end point.

کلیدواژه‌ها

cardiac troponin I؛ Dog؛ hemorrhagic shock

مراجع

1. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction

redefined: A consensus document of the Joint European

Society of Cardiology/ American College of Cardiology

Committee for the Redefinition of Myocardial Infarction. J

Am Coll Cardiol. 2000 Sep;36(3):959-69.

2. Archie JP, Mertz WR. Myocardial oxygen delivery after experimental

hemorrhagic shock. Ann Surg. 1978 Feb;187(2):205-

10.

3. Arlati S, Brenna S, Prencipe L, Marocchi A, Casella GP, Lanzani

M, et al. Myocardial necrosis in ICU patients with acute

non-cardiac disease: a prospective study. Intensive Care Med.

2000 Jan;26(1):31-7.

4. Baue AE, Tragus ET, Wolfson SK Jr, Cary AL, Parkins WM. Hemodynamic

and metabolic effects of Ringer’s lactate solution

in hemorrhagic shock. Ann Surg. 1967 Jul;166(1):29-38.

5. Braz J, Nascimento P, Filho O, Braz L, Vane LA, Galva˜oVianna

PT, et al. The early systemic and gastrointestinal oxygenation

effects of hemorrhagic shock resuscitation with hypertonic

saline and hypertonic saline 6% dextran-70: A comparative

study in dogs. Anesth Analg. 2004 Aug;99(2):536-46.

6. Cheung AT, Driessen B, Jahr JS, Duong PL, Ramanujam S, Chen

PC, et al. Blood substitute resuscitation as a treatment modality

for moderate hypovolemia. Artif Cells Blood Substit

Immobil Biotechnol. 2004 May;32(2):189-207.

7. Cilli F, Alibhai H, Armitage-Chan E, Boswood A, Hammond

RA, Jasani S, et al. Incidence of elevation of cardiac troponin

I prior to and following routine general anaesthesia in dogs.

Vet Anaesth Analg. 2010 Sep;37(5):409-16.

8. Dyson D, Sinclair M. Impact of dopamine or dobutamine infusions

on cardiovascular variables after rapid blood loss and

volume replacement during isoflurane-induced anesthesia in

dogs. Am J Vet Res. 2006 Jul;67(7):1121-30.

9. Hagman R, Lagerstedt AS, Fransson BA, Bergström A, Häggström

J. Cardiac troponin I levels in canine pyometra. Acta

Vet Scand. 2007 Feb 28;49:6.

10. Hamacher L, Dӧrfelt R, Müller M, Wess G. Serum cardiac troponin

I concentrations in dogs with systemic inflammatory

response syndrome. J Vet Intern Med. 2015 Jan;29(1):164-70.

11. Haskins S, Pascoe PJ, Ilkiw JE, Fudge J, Hopper K, Aldrich J.

Reference cardiopulmonary values in normal dogs. Comp

Med. 2005 Apr;55(2):156-61.

12. Karpati PC, Rossignol M, Pirot M, Cholley B, Vicaut E, Henry

P, et al. High incidence of myocardial ischemia during postpartum

hemorrhage. Anesthesiology. 2004 Jan;100(1):30-6.

13. Keefe J. Shock and Initial Stabilization. In: Norkus C, editor.

Veterinary Technician’s Manual for Small Animal Emergency

and Critical Care. 1st ed. Iowa: Wiley-Blackwell; 2012.

14. Ko JJ, Alam R, Kim NS. Hemodynamic effects of fluid resuscitation

with 6% hydroxyethyl starch and whole blood in experimental

hypovolemic shock in Beagle dogs. Turk J Vet Anim

Sci. 2012 Jan;36(4):416-23.

15. Lopes PC, Sousa MG, Camacho AA, Carareto R, Nishimori

CT, Santos PS, et al. Comparison between two methods for

cardiac output measurement in propofol-anesthetized dogs:

thermodilution and Doppler. Vet Anaesth Analg. 2010

Sep;37(5):401-8.

16. Marik P. Hemodynamic parameters to guide fluid therapy.

Transfus Altern Transfus Med. 2010 Sep;11(3):102-112.

17. Moore KE, Murtaugh RJ. Pathophysiologic characteristics of

hypovolemic shock. Vet Clin North Am Small Anim Pract.

2001 Nov;31(6):1115-28.

18. Murakawa K, Kobayashi A. Effects of vasopressors on renal

tissue gas tensions during hemorrhagic shock in dogs. Crit

Care Med. 1988 Aug;16(8):789-92.

19. Nascimento P.Jr, De Paiva Filho O, de

Carvalho LR, Braz JR. Early Hemodynamic

and Renal Effects of Hemorrhagic

Shock Resuscitation with Lactated

Ringer’s Solution, Hydroxyethyl

Starch, and Hypertonic Saline with or

without 6% Dextran-70. J Surg Res.

2006 Nov;136(1):98-105.

20. Oyama MA, Sisson DD. Cardiac troponin-

I concentration in dogs with

cardiac disease. J Vet Intern Med.

2004 Nov-Dec;18(6):831-9.

21. Oyama MA, Solter PF. Validation of an

immunoassay for measurement of canine

cardiac troponin-I. J Vet Cardiol.

2004 Nov;6(2):17-24.

22. Schober K, Cornand C, Kirbach B,

Aupperle H, Oechtering G. Serum

cardiac troponin I and cardiac troponin

T concentrations in dogs with

gastric dilatation-volvulus. J Am Vet

Med Assoc. 2002 Aug 1;221(3):381-8.

23. Strickland KN. Pathophysiology and

Therapy of Heart Failure. In: Smith

FWK, Tilley LP, Oyama MA, Sleeper

MM, editors. Manual of canine and

feline cardiology. 5th ed. Missouri:

Elsevier; 2016.

24. Udelsmann A, Bonfim MR, Silva WA,

Moraes AC. Hemodynamic effects

of volume replacement with saline

solution and hypertonic hydroxyethyl

starch in dogs. Acta Cir Bras. 2009

Mar-Apr;24(2):87-92.

25. Vincent JL, Dufaye P, Berre J, Leeman

M, Degaute JP, Kahn RJ. Serial

lactate determinations during circulatory

shock. Crit Care Med. 1983

Jun;11(6):449-51.