The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats

Iranian Journal of Veterinary Science and Technology

مقاله 7، دوره 12، شماره 2 - شماره پیاپی 23، اسفند 2020، صفحه 50-58   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/ijvst.2021.64211.0

نویسندگان

Keyvan Hejazi¹؛ Mohammad Mosaferi Ziaaldini,^{* 2}؛ Seyyed Reza Attarzadeh Hosseini³؛ Mehrdad Fathi⁴

¹Department of Sport Sciences, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.

²Department of Sport Sciences, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

³Department of exercise physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

⁴Department of exercise physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

چکیده

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is the main regulator in energy metabolism. Training stimulates many processes like mitochondrial biogenesis, glucose metabolism, and fatty acids metabolism. It also increases the capacity of fat oxidation. The purpose of this study was to investigate the effects of eight-week aerobic training of different intensities on PGC-1α, interferon regulatory factor 4 (IRF4), and atherogenic index in obese male Wistar rats. Twenty-four obese male rats induced by a high-fat diet (weight: 250 to 300 gr, BMI >30g/cm2) were divided into three groups: aerobic training of moderate intensity (MI), aerobic training of high intensity (HI), and the control group (C). The MI and HI training groups carried out exercise training by eight weeks of walking on a treadmill for five sessions/week, 60 min per session, and at a speed of 28 m/min and 34 m/min, respectively. The levels of PGC-1a in the MI and HI groups significantly increased compared to the C group (p < 0.05). Moreover, there was no significant differences between IRF4 levels of MI and HI groups (p > 0.05). The serum HDL-C levels increased only in the MI group compared to the C group (p  < 0.05). The LDL-C, TG, TC, and atherogenic index levels reduced more significantly in MI and HI groups than in the C group (p  < 0.05). The results show that eight-week aerobic training of two moderate and high intensities may be the signaling pathways to the activation of the PGC-1a protein (i.e., a key regulator of energy metabolism and mitochondrial biogenesis) in skeletal muscle.

کلیدواژه‌ها

Aerobic training؛ PGC-1α؛ IRF4؛ atherogenic index

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