Influence of Acute Workouts on the BDNF Levels in Hippocampus-exposed Rats

Research in Exercise and Sports Medicine

دوره 4، شماره 2، بهمن 2013، صفحه 25-30   

نوع مقاله: Original Article

چکیده

Purpose: It was shown that with acute low-intensity exercise that is minimally stressful, hippocampus 
activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield 
greater benefits in hippocampus functions compared to the more strenuous forms. The neuroprotective effects 
of acute workout training on lead acetate-induced BDNF levels were investigated. 
Material and Methods: Thirty -two adult, male, Wistar rats were randomly classified into 4 groups; Rats 
were randomly assigned to 1) basic group (Base-B, n = 10), 2) control group (lead-L, n=10) 3), lead injection 
group (acute pre, n=10) and 4) treadmill exercise with lead injection group (acute post, n=10). The rats in 
groups 3 and 4 experienced the treadmill running 15 to 22m/min, 25 to 64minutes, 5 times a week, and for 8 
weeks. Groups 3 and 4 received lead acetate (20 mg/kg) and the sham group received solvent (ethyl oleat).
Results: The results showed that BDNF in Lead acetate group decreased significantly whereas it increased in 
Lead acetate + Workout group. Obtained data suggest a lifestyle-induced protective potential in rehabilitation 
of lead-induced neurodegeneration.
Discussion and Conclusion: findings from the present research indicated the significant role of exercises in 
improving BDNF level. Increased level of BDNF may act as neuroprotector in recovery from numerous 
disturbances, such as reduction of the brain weight, memory loss and different degenerative processes. It may 
be concluded that the increase of BDNF in hippocampus may cause positive plastic changes and prevent the 
mentioned disturbance

کلیدواژه‌ها

Acute workout؛ Brain-derived neurotrophic factor؛ Hippocampus؛ Lead acetate