استفاده مدل‌های اصطکاکی نوین به منظور بررسی خواص مکانیکی بافت سرطانی کبد

علوم کاربردی و محاسباتی در مکانیک

مقاله 8، دوره 36، شماره 3 - شماره پیاپی 37، شهریور 1403، صفحه 107-122   

نوع مقاله: مقاله پژوهشی

شناسه دیجیتال (DOI): 10.22067/jacsm.2024.87206.1245

نویسندگان

معین طاهری^* ؛ زهرا سادات اقدامی

مهندسی مکانیک، دانشگاه اراک، اراک، ایران

چکیده

امروزه سرطان کبد جابگاه ششم در میان سرطان ها و رتبه چهارم از علل مرگ و میر را به خود اختصاص داده است. بررسی وضعیت بدن و شناخت زودهنگام این بیماری می‌تواند در کنترل و درمان آن موثر باشد. بررسی خواص مکانیکی بافت کبد و مطالعه مدول یانگ آن موجب شناسایی وضعیت سلامت بافت و بیمار خواهد شد. در این پژوهش با استفاده از مدل‌های اصطکاکی دال، انتگرال‌گیری بازنشانی و مدل‌های بلیمن و سورین، به محاسبه مدول یانگ به صورت تئوری پرداخته شده است. همچنین با استفاده از میکروسکوپ نیروی اتمی این مدول به صورت تجربی استخراج شده است. مقایسه مدول‌های تئوری و تجربی به دست آمده، نتایجی نزدیک به هم خواهد داشت. با توجه به بررسی بافت و روابط در سطح نانو، مدل دوم بیلمن و سورین به دلیل کمتر بودن دامنه تغییرات و معادلات پیچیده تر، از دقت بالاتری برخوردار است. بنابراین استفاده از مدل دوم بیلمن و سورین در پژوهش‌های آتی پیشهاد می‌شود.

کلیدواژه‌ها

بافت سرطانی کبد؛ مدل اصطکاکی دال؛ انتگرال‌گیری بازنشانی؛ مدل‌های اصطکاکی بلیمن و سورین؛ میکروسکوپ نیروی اتمی

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