Eight Weeks of Progressive Resistance Training Increased the Content of UCP1 in Visceral and Subcutaneous Adipose Tissue of Rats

Journal of Cell and Molecular Research

مقاله 4، دوره 16، شماره 1 - شماره پیاپی 31، دی 2024، صفحه 36-46   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/jcmr.2024.87131.1088

نویسندگان

Hani Firooz-zare¹؛ Alireza Safarzade^{* 1، 2}؛ Elahe Talebi-Garakani^{1، 2}

¹Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran

²Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran

چکیده

New evidence indicates that exercise training as a stimulant of adipose tissue thermogenesis can play a positive role in preventing obesity. The purpose of this research is to investigate the effect of eight weeks of progressive resistance training on the levels of proteins involved in the thermogenesis of visceral and subcutaneous adipose tissues in sucrosefed rats. Twenty- four male Wistar rats (222±26g, 4- 6 weeks) were divided into normal control, sucrose control, and progressive resistance training groups. The normal control group was fed only standard food and water. In addition to free access to water and standard food, the other two groups were fed a 10% sucrose solution. The exercise program started after two months of nutritional intervention and continued for 8 weeks, 3 days a week. 72 hours after the last training session and after 4 hours of fasting, the rats were anesthetized, and blood samples and visceral and subcutaneous adipose tissues were taken. Serum glucose and insulin levels and insulin resistance index along with tissue levels of PGC1α and UCP1 were measured. The results showed that the consumption of sucrose solution significantly increased serum glucose (P≥0.001) and insulin (P≥0.001) levels and insulin resistance index (P≥0.001) and decreased UCP1 levels in subcutaneous fat tissue (P≥0.03) compared to the control group. Also, progressive resistance training caused a significant decrease in insulin (P≥0.007), insulin resistance index (P≥0.025), and increased UCP1 levels in visceral(P≥0.032) and subcutaneous (P≥0.005) adipose tissue compared to the sucrose control group. However, the levels of PGC1α in visceral and subcutaneous fat tissues did not show any significant changes. The results showed that progressive resistance training, in addition to improving insulin sensitivity, can play an effective role in the process of browning white adipose tissue by increasing the level of UCP1 in visceral and subcutaneous adipose tissue, and as a therapeutic method for improving insulin resistance and obesity.

کلیدواژه‌ها

Progressive Resistance Training؛ insulin resistance؛ UCP1؛ PGC-1&alpha

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