شبکههای فلزی– فنولی به عنوان رابط زیستی ضدمیکروبی و ضدسرطانی در کاربردهای زیستپزشکی
مهندسی متالورژی و مواد
مقاله 3 ، دوره 35، شماره 4 - شماره پیاپی 36 ، بهمن 1403، صفحه 49-78 اصل مقاله (2.23 M )
نوع مقاله: علمی و پژوهشی
شناسه دیجیتال (DOI): 10.22067/jmme.2024.88514.1150
نویسندگان
شقایق کهزادی ؛ زهرا محمدی*
گروه فناوری پزشکی و مهندسی بافت، آزمایشگاه تخصصی بیوسرامیک و ایمپلنت، دانشکدگان علوم و فناوری های میان رشته ای، دانشگاه تهران
چکیده
شبکههای فلزی- فنولی، یک سیستم شبکه ترکیبی آلی- معدنی در حال ظهورند که بهتدریج در سالهای اخیر توسعه یافته است و با استفاده از هماهنگی بین یونهای فلزی و لیگاندهای آلی حاوی گروههای فنول، مانند گالول یا کاتکول، ویژگیها چندمنظوره عالی نظیر خواص ضدالتهابی، آنتیاکسیدانی و ضدباکتریایی را از خود نشان دادهاند. این مواد خواص سطح را به طور قابل توجهی تغییر میدهند و میتوانند منجر به بهبود عملکرد در رفتارهایی مانند مقاومت به خوردگی، آبگریزی، زیستسازگاری و اتصال مولکولهای خاص به سطوح مختلف، ازجمله فلزات، اکسیدها، پلیمرها و مواد زیستی شوند. علاوه بر این، شبکههای فلزی- فنولی به دلیل فرآیند سنتز آسان، زیستسازگاری عالی و خواص ضدمیکروبی برجسته ناشی از حضور پلیفنولها و یونهای فلزی، توجه گستردهای را در جلوگیری از عفونتها و ایجاد روشهای درمانی پیشرفته سرطان به خود جلب کردهاند. هدف این مقاله، مروری بر کاربردهای اخیر زیستپزشکی شبکههای فلزی- فنولی در ساختارهای مختلف با تمرکز بر خواص ذاتی آنها از جمله خواص ضدمیکروبی و ضدسرطانی جدید است.
کلیدواژهها
شبکههای فلزی- فنولی" ؛ رابط زیستی" ؛ ضدمیکروب" ؛ " ؛ ضدسرطان"
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