Preliminary Evaluation of the Therapeutic Effects of Neem Leaf Extract and Ivermectin in West African Dwarf Goats with Clinical Mange

Iranian Journal of Veterinary Science and Technology

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 تیر 1404   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijvst.2025.93101.1504

نویسندگان

Olubunmi Titilayo Ojoawo^{* 1}؛ Jelili Akinwole Akinlade²؛ Opeyemi Agbeniyi³؛ Opeyemi Oladipupo Hammed⁴؛ Fiwasade Adejoke Rom-Kalilu⁴

¹Department of Animal Production and Health, Faculty of Agricultural Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

²Department of Animal Production and Health, Ladoke Akintola University of Technology

³Department of Animal Production and Health. Faculty of Agricultural Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

⁴Department of Animal Production and Health, Faculty of Agricultural Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.

چکیده

This study investigates the effectiveness of neem (Azadirachta indica) extract as a topical treatment for mange in West African Dwarf (WAD) goats, a breed commonly raised in Southern Nigeria and are affected by mange, which undermines animal welfare and productivity. Twelve mange-infected goats were randomly assigned to three treatment groups: T1 (10 ml ivermectin pour-on), T2 (5 ml neem extract + 5 ml ivermectin), and T3 (10 ml neem extract). Treatments were applied over 14 days, and data were collected on skin scrapings, red blood cell (RBC) count, white blood cell (WBC) count and serum biochemical indices. Phytochemical analysis of neem extract revealed notable levels of alkaloids, saponins, and phenols. All groups showed improved skin condition post-treatment, with significant increases in RBC and WBC counts observed in T2 goats (P<0.05). Differences in serum biochemical indices, particularly potassium, were also noted. Findings indicate that neem extract can serve as an effective alternative or adjunct treatment to ivermectin for mange control in WAD goats reared in the local environments with poor accesibility to conventional drugs, improving animal health and production outcomes.

کلیدواژه‌ها

Neem leaf؛ Ivermectin؛ Mange؛ West African Dwarf goats؛ Topical؛ Food security