A comparative study on Echinococcus granulosus and curcumin therapeutic effect in mouse model of multiple sclerosis

Iranian Journal of Veterinary Science and Technology

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 مهر 1404   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijvst.2025.93963.1562

نویسندگان

yaser Jafari-Khataylou^{* 1}؛ Seyyed Jamal Emami²؛ Abbas Imani Baran³؛ Somayeh Ahmadiafshar⁴

¹Department of pathobiology, Faculty of veterinary medicine, University of Tabriz, Tabriz, Iran

²Division of Epidemiology and Zoonoses, Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

³Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

⁴Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

چکیده

Multiple sclerosis is a chronic autoimmune disease of the central nervous system, characterized by demyelination and neurodegeneration of the brain, spinal cord. Echinococcus granulosus the causative agent of Cystic echinococcosis induces host immunomodulation which protect it from the anti-parasitic immune response. Curcumin is a natural polyphenol component with proved anti-inflammatory and antioxidant properties. Current study was conducted to explore the immunomodulatory effects of Echinococcus granulosus protoscolices in experimental autoimmune encephalomyelitis as a model of multiple sclerosis in rats and to compare it with therapeutic effect of curcumin. 40 Sprague Dawley rats were randomly divided into four groups, include: normal control, experimental autoimmune encephalomyelitis group, experimental autoimmune encephalomyelitisrats treated with Echinococcus granulosus protoscolices and experimental autoimmune encephalomyelitisrats treated with curcumin. Proinflammatory cytokines, brain nitric oxide concentration, serum myeloperoxidase activity and serum malondialdehyde level was evaluated. Based on our results, experimental autoimmune encephalomyelitiscaused significant increase in proinflammatory cytokines, myeloperoxidase activity, malondialdehyde levels and nitric oxide concentration as compared with the control group. Treatment with curcumin and Echinococcus granulosus protoscolices reduced the release of inflammatory cytokines, myeloperoxidase activity, malondialdehyde levels and nitric oxide concentration compared to experimental autoimmune encephalomyelitis group. No difference was observed between curcumin and Echinococcus granulosus protoscolices treated groups. The results of current study showed that Echinococcus granulosus protoscolices confer a therapeutic effect on experimental autoimmune encephalomyelitis as a model of Multiple sclerosis by decreasing the production of pro-inflammatory cytokines and inhibiting oxidative stress.The similar role was observed for curcumin. The efficacy of Echinococcus granulosus protoscolices was equal to curcumin.

کلیدواژه‌ها

Curcumin؛ Echinococcus granulosus؛ Experimental autoimmune encephalomyelitis (EAE)؛ Multiple sclerosis؛ cytokine