Bioactivity Comparison of Silk Fibroin/Nano-Titanium Dioxide and Silk Fibroin/Nano-Titanium Dioxide Containing Flour Ions for Bone Tissue Engineering

مهندسی متالورژی و مواد

Article 6, Volume 32, Issue 1 - Serial Number 23, June 2021, Pages 75-84   

Document Type: Original Articles

DOI: 10.22067/ma.v32i1.80791

Authors

Narges Johari^{* 1}; Hamid Reza Madaah Hosseini²; Ali Samadikuchaksaraei³

¹Department of Materials Science and Engineering, Golpayegan University of Technology, Golpayegan, Iran.

²Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran.

³Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Bone defects and developed surgery with low injuries have conducted researches to design and produce composites containing biodegradable polymer and bioactive ceramic, introducing as a biocompatible scaffold for bone tissue engineering. In the present study, bioactive nanocomposite scaffolds of silk fibroin/titanium dioxide nanoparticles (SF/TiO₂) and silk fibroin/titanium dioxide nanoparticles which contain flour ions (SF/TiO₂-F) were prepared. Accordingly, flour ions were bound to TiO₂ nanoparticles and both SF/TiO₂ and SF/TiO₂-F scaffolds were produced. Then, the bioactivity and apatite formation on the surface of prepared scaffolds were evaluated by immersing in simulated body fluid (SBF) for 28 days. As a resultant, SF/TiO₂-F scaffolds showed improved bioactivity in comparison with SF/TiO₂ ones, as such, after 12 days of immersion in SBF, apatite precipitations covered around 40 %  of surface of prepared scaffolds. 

Keywords

Bioactive scaffold; Fibroin; Titanium dioxide nanoparticles; Flour ion

Supplementary Files

6-Johari-revised.pdf

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