Hydroalcoholic extracts of three Artemisia species attenuate dental pulp pain and pain-related abnormal feeding behavior of rats

Iranian Journal of Veterinary Science and Technology

دوره 14، شماره 2 - شماره پیاپی 27، شهریور 2022، صفحه 29-37   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/ijvst.2022.72372.1075

نویسندگان

Jahangir Haghani¹؛ Fatemeh Haghani²؛ Amirhosein Soleimani³؛ Mehdi Abbasnejad⁴؛ Mojteba Khodami⁵؛ Razieh Kooshki^{* 6}؛ Maryam Raoof⁷

¹Endodontology Research Center, Kerman University of Medical Sciences, Kerman, Iran.

²Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

³Physiology Department, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

⁴Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

⁵Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran

⁶Department of biology, Faculty of Science, Lorestan University, Khorramabad, Iran.

⁷epartment of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

چکیده

This study considered the therapeutic efficacy of three different Artemisia species extracts on capsaicin-induced dental pulp pain and pain-associated changes in feeding behaviors in adult male Wistar rats. The animals were alienated into five groups (n=6), comprising: sham, capsaicin, and capsaicin groups pre-treated with hydroalcoholic extracts of A. sieberi, A.persica, and A.biennis. Pulpitis was evoked by intradental administration of capsaicin (100 µg). The plant extracts (200 mg/kg/ i.p.) were administered 10 min before capsaicin. Pain scores were recorded for forty min. Afterward, feeding behavior was evaluated within 6 hours. All extracts could suppress capsaicin-related dental pulp pain. Furthermore, capsaicin decreased the number of visits to the food and water ports of the feeding behavior evaluation device that led to a reduced amount and duration of meals consumed. These harmful effects of capsaicin on meal duration, and frequency were attenuated by A.persica. Moreover, capsaicin inhibitory effect on food intake and water consumption was suppressed by all the extracts. Taken together, the present study showed that Artemisia species extracts are useful in supressing capsaicin-induced pulpal pain and pain-induced feeding abnormalities.

کلیدواژه‌ها

Pulpitis؛ Capsaicin؛ Food intake؛ Artemisia؛ Rats

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