Ovine and Caprine Toxoplasmosis (Toxoplasma gondii)

Iranian Journal of Veterinary Science and Technology

مقاله 1، دوره 2، شماره 2، آذر 2010، صفحه 16-61   

نوع مقاله: Review Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v2i2.8378

نویسندگان

Mohamad A. Abu-Dalbou؛ Mustafa M. Ababneh؛ Nektarios D. Giadinis؛ Shawkat Q. Lafi^*

Jordan University of Science and Technology

چکیده

Toxoplasmosis, caused by Toxoplasma gondii (T. gondii), is an economically important disease of livestock, especially sheep and goats, where it can cause early embryonic death and resorption, fetal death and mummification, abortion, stillbirth, and neonatal death.Cats are the main reservoir for the toxoplasmosis which can contaminate the environments of other animal and human beings by their faeces that contain sporulated oocysts.Toxoplasmosis is diagnosed mainly by direct smear, Immunohistochemistry, serology testing and PCR. Preventive measures include education of the farmers, reduce environmental
contamination by oocysts, reducing the number of cats capable of shedding oocysts, limiting the breeding of cats to maintain healthy adults, control of future breeding and adequate
continuous control programs of stray cats. Feeding cats with commercial diets or with food processed either by cooking or freezing can reduce the risk of disease transmission. A live
vaccine (Toxovax®) is commercially marketed in some countries for reducing losses to the sheep industry from congenital toxoplasmosis. History, Life cycle, Clinical signs, Diagnosis, Mode of transmission, Epidemiology, Treatment, Control, Prevention and Vaccination against T. gondii infection in small animals
have been reviewed in this article.

کلیدواژه‌ها

Toxoplasma gondii؛ Sheep؛ goat؛ abortion؛ diagnosis؛ Control

مراجع

Arantes, T., Lopes, W., Ferreira, R., Pinto Pieroni, J., Pinto, M., Sakamoto, C. and da Costa, A. (2009) Toxoplasma

gondii: Evidence for the transmission by semen in dogs. Experimental Parasitology 123, 190-194.

Beverley, J., Archer, J., Watson, W. and Fawcett, A. (1971) Trial of a killed vaccine in the prevention of ovine abortion due to toxoplasmosis. British Veterinary Journal 127, 529-535.

Bowie, W., King, A., Werker, D., Isaac-Renton, J., Bell, A., Eng, S. and Marion, S. (1997) Outbreak of toxoplasmosis associated with municipal drinking water. The BC Toxoplasma Investigation Team.Lancet 350, 173-177.

Brown, H. and Neva, F. (1987) Basic Clinical Parasitology, 5th edn., Appleton-Century- Crofts, USA.

Buxton, D. (1998) Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances. Veterinary Research 29, 289-310.

Buxton, D., Blewett, D., Trees, A., McColgan,C. and Finlayson, J. (1988) Further studies in the use of monensin in the control of experimental ovine toxoplasmosis. Journal of Comparative

Pathology 98, 225-236.

Buxton, D., Brebner, J., Wright, S., Maley, S.,Thomson, K. and Millard, K. (1996) Decoquinate and the control of experimental ovine toxoplasmosis.Veterinary Record 138, 434-436.

Buxton, D. and Finlayson, J. (1986) Experimental infection of pregnant sheep with Toxoplasma gondii: pathological and immunological observations on the placenta and foetus. Journal of Comparative Pathology 96, 319-333.

Buxton, D. and Innes, E. (1995) A commercial vaccine for ovine toxoplasmosis.Parasitology 110, S11-16.

Buxton, D., Maley, S., Wright, S., Rodger, S.,Bartley, P. and Innes, E. (2007) Toxoplasma gondii and ovine toxoplasmosis: new aspects of an old story. Veterinary Parasitology 149, 25-

28.

Buxton, D. and Rodger, S. (2008) Toxoplasmosis and neosporosis. In:Diseases of sheep, 4th (Aitken, ID.) edn., Wiley-Blackwell, Hoboken.

Buxton, D., Thomson, K. and Maley, S. (1993) Treatment of ovine toxoplasmosis with a combination of sulphamezathine and

pyrimethamine. Veterinary Record 132, 409-411.

Caballero-Ortega, H., Palma, J., Garcia-Marquez, L., Gildo-Cardenas, A. and Correa, D. (2008) Frequency and risk

factors for toxoplasmosis in ovines of various regions of the State of Colima,Mexico. Parasitology 135, 1385-1389.

Cabannes, A., Lucchese, F. and Hernandez, J.(1997) Enquete seroepide-miologique sur Toxoplasma gondii chez les ovins,

bovines et felins dans le department de le Gironde. Bulletin de la Societe de France Parasitologigue 15, 11-22.

Cavalcante, A., Carneiro, M., Gouveia, A.,Pinheiro, R. and Vitor, R. (2008) Risk factors for infection by Toxoplasma gondii in herds of goats in Ceara,Brazil. Arquivo Brasileiro de Medicina

Veterinaria e Zootecnia 60, 36-41.

Chiari, C., Lima, W., Antunes, C. and Lima, J.(1987) Soro-epidemiologia da toxoplasmose caprina em Minas

Gerais, Brasil. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia 39,587-609.

Chiari, C. and Neves, D. (1984) Toxoplasmose humana adquirida atraves da ingestã o de leite de cabra. Memorial Institute of

Oswaldo Cruz 79, 337-340.

Deconinck, P., Pangui, L. and Akakpo, J.(1996) Prevalence de la toxoplasmose chez les petits ruminants en Afrique

tropicale: resultats d’une enquete seroepidemiologique

sur 1042 animaux.Revue de Medecine Veterinaire 147,

377-378.

Denmark, I. and Chessum, B. (1978) Standardization of enzyme-linked immunosorbent assay (ELISA) and the detection of Toxoplasma antibody.Medical Laboratory Science 35, 227-

232.

Dubey, J. (1980) Persistence of encysted Toxoplasma gondii in caprice levers and public health significance of toxoplasmosis in goats. Journal of American Veterinary Medical Association 177, 1203-1207.

Dubey, J. (1984) Experimental toxoplasmosis in sheep fed Toxoplasma gondii oocysts. International Goat and Sheep

Research 2, 93-104.

Dubey, J. (1986) A review of toxoplasmosis in cattle. Journal of Veterinary Parasitology 22, 177-202.

Dubey, J. (1991) Toxoplasmosis--an overview.Journal of tropical medicine and public health 22, 88-92.

Dubey, J. (1994) Toxoplasmosis. Journal of American Veterinary Medical Association 205, 1593-1598.

Dubey, J. (1995) Duration of immunity to shedding of Toxoplasma gondii oocysts by cats. Jounal of Parasitology 81, 410-415.

Dubey, J. (2001) Oocyst shedding by cats fed isolated bradyzoites and comparison of infectivity of bradyzoites of the VEG strain Toxoplasma gondii to cats and mice. Journal of Parasitology 87, 215-219.

Dubey, J. (2004) Toxoplasmosis-a waterborne zoonosis. Veterinary Parasitology 126,57-72.

Dubey, J. (2008) The history of Toxoplasma gondii-the first 100 years. Journal of Eukaryotic Microbiology 55, 467-475.

Dubey, J. (2009) Toxoplasmosis in sheep-The last 20 years. Veterinary Parasitology 163, 1-14.

Dubey, J. and Beattie, C. (1988) Toxoplasmosis of animals and man,CRC Press, Boca Raton, Florida, USA.

Dubey, J. and Carpenter, J. (1993) Neonatal toxoplasmosis in littermate cats.Journal of American Veterinary Medical Association 203, 1546-1549.

Dubey, J., Dorough, K., Jenkins, M., Liddell,S., Speer, C., Kwok, O. and Shen, S.(1998) Canine neosporosis: clinical signs, diagnosis, treatment and isolation of Neospora caninum in mice

and cell culture. International Journal of Parasitology 28, 1293-1304.

Dubey, J. and Frenkel, J. (1972) Cyst-induced toxoplasmosis in cats. Journal of Protozoology 19, v.

Dubey, J. and Jones, J. (2008) Toxoplasma gondii infection in humans and animals in the United States. International

Journal of Parasitology 38, 1257-1278.

Dubey, J. and Sharma, S. (1980) Parasitemia and tissue infection in sheep fed Toxoplasma gondii oocysts. Journal of Parasitology 66, 111-114.

Edelhofer, R. and Aspock, H. (1996) Infektionsquellen und infektionswege aus der Sicht des Toxoplasmose-Screenings der Schwangeren in Osterreich. Mitt Osterr Ges Tropenmed

Parasitol 18, 59-70.

Edvinsson, B., Lappalainen, M., Evengå rd, B.and Toxoplasmosis, E.S.G.f. (2006) Real-time PCR targeting a 529-bp repeat element for diagnosis of toxoplasmosis. clinical microbiology infection 12, 131-136.

Esteban-Redondo, I., Maley, S., Thomson, K.,Nicoll, S., Wright, S., Buxton, D. and Innes, E. (1995) Detection of T. gondii

in tissues of sheep and cattle following oral infection. Veterinary Parasitology 86, 155-171.

Faull, W., Clarkson, M. and Winter, A. (1986) Toxoplasmosis in a flock of sheep: some investigations into its source and

control. Veterinary Record 119, 491-493.

Frenkel, J., Dubey, J. and Miller, N. (1970) Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts. Science

167, 893-896.

Frenkel, J., Ruiz, A. and Chinchilla, M. (1975) Soil survival of Toxoplasma oocysts in Kansas and Costa Rica. American

Journal of Tropical Medicine and Hygiene 24, 439-443.

Gajadhar, A., Meaasures, L., Forbes, L.,Kapel, C. and Dubey, J. (2004) Experimental Toxoplasma gondii infection in grey seals Halichoerus grypus. Jounal of Parasitology 90, 255-259.

Garcia, L. (2001) Tissue protozoa. In: Diagnostic Medical Parasitology, 4th edn., ASM Press, California, USA. pp

132-158.

Giadinis, N., Terpsidis, K., Diakou, A.,Siarkou, V., Karatzias, H. and

Papazahariadou, M. (2009) Treatment of sheep toxoplasmosis with sulfadimidine. In: Proceedings of the World Sheep Veterinary Congress, Stavanger, Norway.

Hartley, W. and Marshall, S. (1957) Toxoplasmosis as a cause of ovine perinatal mortality. New Zealand Veterinary Journal 5, 119-124.

Higa, L., Araú jo, S., Tsuneto, L., Castilho-Pelloso, M., Garcia, J., Santana, R. and Falavigna-Guilherme, A. (2010) A prospective study of Toxoplasmapositive pregnant women in southern

Brazil: a health alert. Transactions of the Royal Society of Tropical Medicine and Hygiene 104, 400-405.

Hutchison, W. (1965) Experimental transmission of Toxoplasma gondii.Nature 206, 961-962.

Hye-Youn, K., Yun-Ah, K., Ho Sa, L., Ho Gun, R., Shin-Hyeong, C., Jae-Ran, Y. and Sang-Eun, L. (2009) Genotype of

Toxoplasma gondii from Blood of Stray Cats in Gyeonggi-do, Korea.Korean Journal of Parasitology 47,413-415.

Innes, E. (2009) A brief history and overview of Toxoplasma gondii. Zoonoses Public Health 57, 1-7.

Jackson, M. and Hutchison, W. (1989) The prevalence and source of Toxoplasma infection in the environment. Advances

in Parasitology 28, 55-105.

Jacobs, L., Remington, J. and Melton, M.(1960) The resistance of the encysted form of toxoplasma gondii. Jounal of

Parasitology 46, 11-21.

Jalal, S., Nord, C., Lappalainen, M., Evengå rd,B. and CMID Study Group on Toxoplasmosis (2004) Rapid and sensitive diagnosis of toxoplasma gondii infections by PCR. Clinical

Microbiology and Infection 10, 937-939.

James, L. (1992) Toxoplasmosis.Encyclopedia of Microbiology 4, 255-264.

Kamani, J., Mani, A. and Egwu, G. (2009) Seroprevalence of Toxoplasma gondii infection in domestic sheep and goats

in Borno state, Nigeria. Tropical Animal Health and Production 21,

134-137.

Kasper, D., Sadeghi, K., Prusa, A., Reischer,G., Kratochwill, K., Fö rster-Waldl, E.,Gerstl, N., Hayde, M., Pollak, A. and Herkner, K. (2009) Quantitative realtime polymerase chain reaction for the

accurate detection of Toxoplasma gondii in amniotic fluid. Diagnostic Microbiology and Infectious Disease 63, 10-15.

Kniel, K., Lindsay, D., Sumner, S., Hackney,C., Pierson, M. and Dubey, J. (2002) Examination of attachment and survival of Toxoplasma gondii oocysts on raspberries and blueberries. Jounal

of Parasitology 88, 790-793.

Lingelbach, K. and Joiner, K. (1998) The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells. Journal of Cell Science 111, 1467-1475.

Lopes, A., Cardoso, L. and Rodrigues, M.(2008) Serological survey of Toxoplasma gondii infection in domestic cats from northeastern Portugal. Veterinary Parasitology 155,184-189.

Lopes, W., da Costa, A., Santana, L., dos Santos, R., Rossanese, W., Lopes, W.,Costa, G., Sakamoto, C. and dos

Santos, T. (2009) Aspects of Toxoplasma Infection on the

Reproductive System of Experimentally Infected Rams (Ovis

Aries). Jounal of Parasitology Research 1155, 1-6.

Markell, E., Voge, M. and John, D. (1992) Medical Parasitology, 7th edn., W.B. Saunders Company England. p 116.

Mason, S., Quinnell, R. and Smith, J. (2010) Detection of Toxoplasma gondii in lambs via PCR screening and serological follow-up. Veterinary Parasitology 169, 258-263.

Matthews, J. (1999) Diseases of goat, 2nd edn., Blackwell Science. pp 26 -28.

McColgan, C., Buxton, D. and Blewett, D.(1988) Titration of Toxoplasma gondii oocysts in non-pregnant sheep and the

effects of subsequent challenge during pregnancy. Veterinary Record 123,467-470.

McHugh, T., Bathgate, T., Mangan, J.,Johnson, J., Holliman, R. and Butcher,P. (1997) Recognition of tissue cystspecific

antigens in reactivating toxoplasmosis. Journal of Medical

Microbiology 46, 587-595.

Menotti, J., Garin, Y., Thulliez, P., Serugue,M., Stanislawiak, J., Ribaud, P., de Castro, N., Houze, S. and Derouin, F.(2010) Evaluation of a new 5'-nuclease real-time PCR assay targeting the

Toxoplasma gondii AF146527 genomic repeat. Clinical Microbiology

and Infection 16, 363-368.

Morley, E., Williams, R., Hughes, J., Terry, R.and Duncanson, P. (2005) Significant familial differences in the frequency of

abortion and Toxoplasma gondii infection within a flock of Charollais sheep. Parasitology 131, 181-185.

Morley, E., Williams, R., Hughes, J.,Thomasson, D., Terry, R., Duncanson, P., Smith, J. and Hide, G. (2008) Evidence that primary infection of Charollais sheep with Toxoplasma gondii may not prevent foetal infection and abortion in subsequent lambings.

Parasitology 135, 169-173.

Moura, A., Costa, A., Filho, J., Paim, B.,Pinto, F. and Di Mauro, D. (2007) Toxoplasma gondii in semen of experimentally infected swine.Pesquisa Veterinaria Brasileira 27,430-434.

Nematollahi, A. and Moghddam, G. (2008) Survey on Seroprevalence of Anti-Toxoplasma Gondii Antibodies in

Cattle in Tabriz (Iran) by IFAT.American Journal of Animal and

Veterinary Sciences 3, 40-42.

Neto, J., Azevedo, S., Gennari, S., Funada, M.,Pena, H., Araú jo, A., Batista, C., Silva,M., Gomes, A., Piatti, R. and Alves, C.

(2008) Prevalence and risk factors for anti-Toxoplasma gondii antibodies in goats of the Serido Oriental microregion, Rio Grande do Norte state, Northeast region of Brazil.Veterinary Parasitology 156, 329–332.

Neufled, J. and Brandt, R. (1974) Cholangiohepatitis in a cat associated with a coccidia like organism.Canadian Veterinary Journal 12, 156-159.

Obendorf, D., Statham, P. and Munday, B.(1990) Resistance to Toxoplasma abortion in female goats previously exposed to Toxoplasmn infection.Australian Veterinary Journal 67, 233-

234.

Piergili Fioretti, D. (2004) Problems and limitations of conventional and innovative methods for the diagnosis of Toxoplasmosis in humans and animals.Parassitologia 46, 177-181.

Plant, J., Richardson, N. and Moyle, G. (1974) Toxoplasma infection and abortion in sheep associated with feeding of grain

contaminated with cat faeces.Australian Veterinary Journal 50, 19-21.

Ragozo, A., Yai LEO, Oliveira, L., Dias, R.,Dubey, J. and Gennari, S. (2008) Seroprevalence and isolation of Toxoplasma gondii from sheep from Sa˜o Paulo State. Braziliann Journal of Parasitology 94, 1259-1263.

Ramzan, M., Akhtar, M., Muhammad, F.,Hussain, I., Hiszczyńska-Sawicka, E.,Haq, A., Mahmood, M. and Hafeez, M.(2009) Seroprevalence of Toxoplasma gondii in sheep and goats in Rahim Yar Khan (Punjab), Pakistan. Tropical Animal Health and Production 41,1225-1229.

Rodger, S., Maley, S., Wright, S., Mackellar,A., Wesley, F., Sales, J. and Buxton, D.(2006) Ovine toxoplasmosis; the role

of endogenous transmission.Veterinary Record 159, 768-772.

Ruiz, A. and Frenkel, J. (1980) Intermediate and transport hosts of Toxoplasma gondii in Costa Rica. American Journal of Tropical Medicine and Hygiene 29, 1161-1166.

Sanger, V., Chamberlani, K., Cole, C. and Farrell, R. (1953) Toxoplasmosis isolation of Toxoplasma gondii from cattle. Journal of American Veterinary Medical Association 123, 87-91.

Scarpelli, L., Lopes, W., Migani, M.,Bresciani, K. and Costa, A. (2009) Toxoplasma gondii in experimentally infected Bos taurus and Bos indicus semen and tissues. Pesquisa Veterinaria Brasileira 29, 59-64.

Schares, G., Vrhovec, M., Pantchev, N.,Herrmann, D. and Conraths, F. (2008) Occurrence of Toxoplasma gondii and

Hammondia hammondi oocysts in the faeces of cats from Germany and other European countries. Veterinary

Parasitology 152, 34-45.

Sibley, D. (2003) Recent origins among ancient parasites. Veterinary Parasitology 115, 185-198.

Spence, J., Mitchell, G., McNally, J., Blewett,D. and Wright, F. (1992) The vaccinal efficacy of the S48 strain“Toxovax” of

Toxoplasma gondii against natural field outbreaks of ovine toxoplasmosis.In: VIth European Multicolloquium of

Parasitology, The Hague. p 103.

Stanley, A., Buxton, D., Innes, E. and Huntley,J. (2004) Intranasal imunisation with Toxoplasma gondii tachyzoite antigen

encapsulated into PLG microspheres induces humoral and cell-mediated immunity in sheep. Vaccine 22, 3929-3941.

Tenter, A., Heckeroth, A. and Weiss, L. (2000) Toxoplasma gondii: from animals to humans. International Jounal of

Parasitology 30, 1217-1258.

Tenter, A., Heckeroth, A. and Weiss, L. (2001) Toxoplasma gondii: from animals to humans. International Jounal of

Parasitology 31, 217-220.

Terpsidis, K., Papazahariadou, M., Taitzoglou,I., Papaioannou, N., Georgiadis, M.and Theodoridis, I. (2009) Toxoplasma

gondii: reproductive parameters in experimentally infected male rats.Experimental Parasitology 121, 238-241.

Van der Puije, W., Bosompem, K., Canacoo,E., Wastling, J. and Akanmori, B.(2000) The prevalence of anti-Toxoplasma gondii antibodies in Ghanaian sheep and goats. Acta Tropica 76, 21-26.

Wahab, T., Edvinsson, B., Palm, D. and Lindh,J. (2010) Comparison of the AF146527 and B1 repeated elements, two realtime PCR targets used for detection of Toxoplasma gondii. Jounal of Clinical Microbiology 48, 591-602.

Wainwright, K., Lagunas-Solar, M., Miller,M., Barr, B., Gardner, I., Pina, C.,Melli, A., Packham, A., Zeng, N., Truong, T. and Conrad, P. (2007a) Physical inacativation of Toxoplasma gondii oocysts in water. Applied and Environmental Microbiology 73, 5663–

5666.

Wainwright, K., Miller, M., Barr, B., Gardner,I., Melli, A., Essert, T., Packham, A.,Truong, T., Lagunas-Solar, M. and

Conrad, P. (2007b) Chemical inactivation of Toxoplasma gondii

oocysts in Water. Jounal of Parasitology 93, 925–931.

Waldeland, H. (1976) The prevalence of Toxoplasma antibodies in lambs and mature sheep from different parts of Norway. Acta Veterinaria Scandinavica 17, 412-432.

Waldeland, H. (1977) Toxoplasmosis in sheep.Influence of various factors on the antibody contents. Acta Veterinaria

Scandinavica 18, 237-247.

Wastling, J., Harkins, D. and Buxton, D.(1994) Western blot analysis of the IgG response of sheep vaccinated with S48

Toxoplasma gondii (Toxovax).Research in Veterinary Science 57,

384-386.

Wastling, J., Nicoll, S. and Buxton, D. (1993) Comparison of two gene amplification methods for the detection of Toxoplasma gondii in experimentally infected sheep. Journal of Medical

Microbiology 38, 360-365.

Wilkins, M., O’Connell, E. and Te Punga, W.(1987) Toxoplasmosis in sheep. I.Effect of a killed vaccine on lamb losses caused by experimental challenge with Toxoplasma gondii.New Zealand Veterinary Journal 35,31-34.

Wilkins, M., O’Connell, E. and Te Punga, W.(1988) Toxoplasmosis in sheep III.Further evaluation of the ability of a live Toxoplasma gondii vaccine to prevent lamb losses and reduce congenital infection following experimental oral challenge. New Zealand Veterinary Journal 36, 86-89.

Woods, L. and Anderson, M. (1992) Scoliosis and hydrocephalus in an ovine fetus infected with Toxoplasma gondii. Journal of Veterinary Diagnostic Investigation 4, 220-222.

Yilmaz, S. and Hopkins, S. (1972) Effects of different conditions on duration of infectivity of Toxoplasma gondii oocysts. Jounal of Parasitology 58,938-939.

Zaki, M. (1995) Seroprevalence of Toxoplasma gondii in domestic

animals in Pakistan. Journal of the Pakistan Medical Association 45, 4-5.