Case report: Follow-up, diagnosis, clinical evidence, laboratory evaluation, and treatment of Idiopathic thrombocytopenia using human Intravenous Immunglobulin in a terrier dog

Iranian Journal of Veterinary Science and Technology

مقاله 8، دوره 6، شماره 1، شهریور 2014، صفحه 64-70   

نوع مقاله: Short communication

شناسه دیجیتال (DOI): 10.22067/veterinary.v6i1.22023

نویسندگان

Ezzatollah Fathi^{* 1}؛ Shahram Jamshidi²

¹University of Tabriz, Tabriz-Iran

²Tehran university, Iran

چکیده

The aim of the present case report is to describe the outcome, hematological and biochemical changes of treatment of idiopathic thrombocytopenia in a Terrier dog using human intravenous immunglobulin. The complete blood count, serum biochemistry, indirect immunofluorescence antibody and direct coomb’s tests, radiography and sonography were performed. Laboratory findings indicated sever thrombocytopenia (

کلیدواژه‌ها

Dog؛ Idiopathic thrombocytopenia؛ Treatment؛ Human intravenous immunoglobulin

مراجع

Bexfield, N.H., Villiers, E.J., and Herrtage, M.E. (2005) Immune-mediated haemolytic anaemia and thrombocytopenia associated with Anaplasma phagocytophilum in a dog. Journal of Small Animal Practice 46, 543–548.

 

Bianco, D., Armstrong, P.J., and Washabau, R.J. (2009) A prospective, randomized, double-blinded, placebo-controlled study of human intravenous immunoglobulin for the acute management of presumptive primary immune-mediated thrombocytopenia in dogs. Journal of Veterinary Internal Medicine 23(5), 1071-1078.

 

Botsch, V., Ku chenhoff, H., and Hartmann, K. (2009) Retrospective study of 871 dogs with thrombocytopenia. Veterinary Record 164, 647–651.

 

Duval, D. and Giger, U. (1996) Vaccineassociated immune-mediated hemolytic anemia in the dog. Journal of Veterinary Internal Medicine 10, 290-295.

 

France, E.K., Glanz, J., and Xu, S. (2008) Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children. Pediatrics 121, 687–692.

 

Hay, F.C., and Westwood, O.M.R. (2002) Practical immunology, 4th edn., Oxford, Blackwell.

 

Huang, A.A., Moore, G.E., and Scott-Moncrieff, J.C. (2012) Idiopathic Immune-Mediated Thrombocytopenia and Recent Vaccination in Dogs. Journal of Veterinary Internal Medicine 26, 142–148.

 

Janeway, C.A., Travers, P., Walport, M., and Schlomchik, M. (2005) Immunobiology: The Immune System in Health and Disease New York. Garland Science Publishing 85–89.

 

Karlikaya, G., Yuksel, G., Yildirim, B., Orken, C., and Tireli, H. (2007) Intravenous Immunglobulin Treatment; The Effect On Different Hematological and Biochemical Parameters. Journal of Neurological Sciences 11, 104-108.

 

Kurata, Y., Fujimura, K., Kuwana, M., Tomiyama, Y and Murata, M. (2011) Epidemiology of primary immune thrombocytopenia in children and adults in Japan: a population-based study and literature review. International Journal of Hematology 93(3), 329-335.

 

Lee, K.Y., Lee, H.S., Hong, J.H., Han, J.Q., Lee, J.S., and Whang, K.T. (2005) High dose intravenous immunoglobulin downregulates the activated levels of inflammatory indices except erythrocyte sedimentation rate in acute stage of Kawasaki Disease. Journal of Tropical Pediatrics 51(2), 98-101.

Lemieux, R., Bazin, R., and Neron, S. (2005) Therapeutic intravenous immunoglobulins. Molecular Immunology 42, 839-848.

 

Marion, L., and Kruth Jackson, A. (1985) Immune-mediated Hemolytic Anemia and Thrombocytopenia in the Dog: A retrospective study of 55 cases diagnosed from 1979 through 1983 at the Western College of Veterinary Medicine. Canadian Veterinary Journal 26(8), 245-250.

 

O'Marra, S.K., Delaforcade, A.M., and Shaw, S.P. (2011) Treatment and predictors of outcome in dogs with immune-mediated thrombocytopenia. Journal of the American Veterinary Medical Association 238(3), 346-352.

 

Scorpio, D.G., Wachtman, L.M., Tunin, R.S., Barat, N.C., Garyu, J.W., and Dumler, J.S. (2008) Retrospective clinical and molecular analysis of conditioned laboratory dogs (Canis familiaris) with serologic reactions to Ehrlichia canis, Borrelia burgdorferi, and Rickettsia rickettsii. Journal of the American Association for Laboratory Animal Sciences 47, 23-28.

 

Scott-Moncrieff, J.C., and Reagan, W.J. (1997) Human intravenous immunoglobulin therapy. Seminars in Veterinary Medicine and Surgery (small Animal) 12(3),178-185.

 

Smedile, L.E., Houston, D.M., Taylor, S.M., Post, K., and Searcy, G.P. (1997) Idiopathic, asymptomatic thrombocytopenia in Cavalier King Charles spaniels: 11 cases (1983-1993). Journal of the American Animal Hospital Association 33(5), 411-415.

 

Waner, T., Leykin, I., and Shinitsky, M. (2000) Detection of platelet- bound antibodies in Beagle dogs after artificial infection with Ehrlichia canis. Veterinary Immunology and Immunopathology 77, 145–150.