Central interaction of ascorbic acid and D2 dopamine receptors on spatial learning and memory in adult male rats

Iranian Journal of Veterinary Science and Technology

مقاله 1، دوره 6، شماره 1، شهریور 2014، صفحه 1-15   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v6i1.23148

نویسندگان

Sima Nasri¹؛ Mehri Bahaaddini²؛ mehdi abbasnejad^{* 3}؛ Saeed Esmaeili-Mahani⁴؛ Ramin Raoof⁵

¹Payam Noor University of Tehran

²Taalim and Tarbiat Colledge of Kerman

³Shahid Bahonar University

⁴Shahid Bahonar University of Kerman, Iran

⁵Shahid Bahonar University of Kerman

چکیده

Previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. Both ascorbic acid and dopamine receptor have an important role in learning and memory processes. However, the central interaction between ascorbic acid and dopamine D2 receptor on spatial learning and memory has not yet been elucidated.
All experiments were carried out on male Wistar rats. Animals were subjected to 5 days of training in the Morris water maze (MWM) task; 4 days with an invisible platform to test special learning and the 5th day with a visible platform to test motivation and sensorimotor coordination.
The data showed that ascorbic acid (25 µg, i.c.v.) could improve spatial learning and memory indices. Administration of bromocriptine, a D2 agonist, increased the effect of ascorbic acid, while treatment with the selective D2 antagonist sulpiride resulted in prevention of the ascorbate-induced memory consolidation. These results indicate that dopamine D2 receptors may be involved in ascorbic acid-induced learning and memory impairment.

کلیدواژه‌ها

Ascorbic acid؛ dopamine D2 receptors؛ learning and memory؛ morris water maze؛ rats water maze؛ Rats

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