The pluripotency feature of cancer cells; product of a harmony or an output of a disharmony

Journal of Cell and Molecular Research

مقاله 1، دوره 6، شماره 2 - شماره پیاپی 12، فروردین 2014، صفحه 50-51   

نوع مقاله: Editorial

شناسه دیجیتال (DOI): 10.22067/jcmr.v6i2.32838

نویسنده

Hesam Dehghani^*

Ferdowsi University of Mashhad

چکیده

Pluripotency is a central feature of stem and cancer cells. This feature enables cancer cells to self-renew and trans-differentiate. In this editorial, it is hypothesized that in cancer cells synchronized events rather than segmented procedures may lead to pluripotency.

کلیدواژه‌ها

pluripotency؛ Stem cells؛ Cancer cells

مراجع

Dehghani H., Dellaire G. and Bazett-Jones D.P. (2005) Organization of chromatin in the interphase mammalian cell. Micron 36(2): p. 95-108.

Efroni S., et al. (2008) Global transcription in pluripotent embryonic stem cells. Cell Stem Cell 2(5): p. 437-47.

Gaspar-Maia A., et al.(2011) Open chromatin in pluripotency and reprogramming. Nature Reviews Molecular Cell Biology,. 12(1): p. 36-47.

Apostolou P., et al.(2012) Cancer stem cells stemness transcription factors expression correlates with breast cancer disease stage. Current Stem Cell Research Therapy 7(6): p. 415-9.

Liu A., Yu X. and Liu S. (2013) Pluripotency transcription factors and cancer stem cells: small genes make a big difference. Clinical Journal of Cancer 32(9): p. 483-7.

Hann S. R. (2014) MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes. Cold Spring Harb Perspect Med.

Hurlin P.J., (2013) Control of vertebrate development by MYC. Cold Spring HarbPerspect Med,. 3(9): p. a014332.

Hirasaki M., et al., (2013) Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs. PLoS One 8(12): p. e83769.

Chappell J. and DaltonS. (2013) Roles for MYC in the establishment and maintenance of pluripotency. Cold Spring HarbPerspect Med 3(12): p. a014381.

Shekhani M.T., et al.(2013) Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies. American Journal of Stem Cells 2(1): p. 52-61.

Barneda-Zahonero, B., et al. (2012) Epigenetic regulation of B lymphocyte differentiation, transdifferentiation, and reprogramming. Computer Functional Genomics 2012: p. 564381.

Sabe H., (2011) Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor beta signalling. Journal of Biochemistry 149(6): p. 633-9.