Is inflammatory pulpal pain a risk factor for amnesia?

Iranian Journal of Veterinary Science and Technology

مقاله 7، دوره 6، شماره 2، 2014، صفحه 62-76   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v6i2.33591

نویسندگان

Maryam Raoof^{* 1}؛ Ramin Raoof¹؛ Mehdi Abbasnejad²؛ Saeed Esmaeili Mahani²؛ Mohsen Ramezani³؛ Hamed Ebrahim nejad⁴؛ Sara Amanpour¹؛ Jahangir Haghani¹

¹Kerman University of Medical Sciences

²Shahid Bahonar University

³Mazandaran University of Medical Sciences

⁴Mashhad University of Medical Sciences

چکیده

The aim of this study was to investigate the effect of inflammatory pulpal pain on spatial learning and memory in male Wistar rats. Fifty-six adult rats were divided into eight groups as follows (n=7 per group): control, sham-operated group that received normal saline, sham vehicle group that received vehicle of capsaicin, three capsaicin treated groups that received intradental injection of 10, 25 and 100 μg capsaicin, respectively, formalin treated group that received 10 μl formalin 2.5% and ibuprofen treated group that received ibuprofen 20 min before capsaicin (100 μg) injection. After preparing cavities via cutting 2 mm of the distal extremities of the mandibular incisors, the polyethylene crowns were placed on the teeth. Based on the study group, different algesics were administrated under the crowns. After recording the pain scores, spatial learning and memory was assessed using Morris water maze test. Capsaicin 25, 100 μg and formalin 2.5% applications induced significantly more painful stimulation compared with control groups (p< 0.001). Capsaicin 25, 100 μg and also formalin-treated groups significantly showed increased escape latency and traveled distance (p

کلیدواژه‌ها

odontalgia, capsaicin؛ formalin؛ spatial learning and memory؛ morris water maze

مراجع