Annexin A1, A2 and cytokine levels during experimental sepsis in calves

Iranian Journal of Veterinary Science and Technology

مقاله 1، دوره 9، شماره 1 - شماره پیاپی 16، 2017، صفحه 1-6   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v9i1.54965

نویسندگان

Mohammad Reza Mokhber Dezfouli¹؛ Zohre Eftekhari^{* 2}؛ Masoomeh Heidari Sureshjani³؛ Mohammad Mahdi Dehghan¹

¹University of Tehran

²Research & Production Complex, Pasteur Institute of Iran, Tehran, Iran

³University of tehran

چکیده

Annexins are fundamentally related proteins that process a variety of physiologic and pathologic procedures, including suppression of inflammation. Ten Holstein-Frisian bull calves (10 ± 1 days old) weighting 50 ± 5 kg were chosen to induce the experimental septicaemia using O111:H8 strain of E. coli. Blood samples were collected to determine the plasma annexin A1 , annexin A2, TNF-α, IFN- γ, IL-8 and neutrophil count at 0, 24, 48, 72, 96 and 120 hours after induction of septicemia. Significant increased concentrations of serum annexin A1 and annexin A2 in circulating blood in response to experimental coliseptisemia were observed during experiment. Maximum levels of annexinA1 and A2 were recorded at 72h after challenge. A statistically significant increase in
blood neutrophil count occurred from beginning of septicemia untill 24h after onset of septicemia. Annexin A2 and Annexin A1 had no significant correlation with neutrophil count. Serum cytokine concentrations reached their maximum level at 48h after challenge and then decreased to basal level before antibiotic therapy. This study showed that serum annexin concentrations, increasing during colisepticemia in calves, in association with cytokines could be a reliable marker to confirm the occurrence of anti-inflammatory response.

کلیدواژه‌ها

Annexin؛ calves؛ cytokines؛ E.coli

مراجع