Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent

Iranian Journal of Veterinary Science and Technology

مقاله 1، دوره 10، شماره 2 - شماره پیاپی 19، شهریور 2018، صفحه 17-21   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v2i10.71626

نویسندگان

Hamid Beyzaei¹؛ Abbas Jamshidian²؛ Mohammad Reza Hajinezhad²؛ Seyed Hadi Hashemi³؛ Nasim Amel⁴؛ Maliheh Abdollahi⁵؛ Fatemeh Arab-Sahebi⁶؛ Behzad Ghasemi^{* 7}

¹University of Zabol,

²University of Zabol

³Zabol University

⁴Torbat Heydariyeh University of Medical Sciences of Torbat

⁵Torbat Jam Faculty of Medical Sciences,

⁶Sabzevar University of Medical Sciences

⁷Torbat Jam Faculty of Medical Sciences,

چکیده

The spread of antibiotic-resistant bacteria in many humans and animals has driven researches to identify and design novel antibacterial agents. In vitro inhibitory activity of (2E)-2-(4,5-dihydro-4-oxothiazol-2-yl)-2-(thiazolidin-2-ylidene) acetonitrile against many bacterial pathogens has been proven in both veterinary and human medicine. In this study, its in vivo toxic effects was studied in mice. The median lethal dose (LD50) value of 239.88 mg/kg was estimated using intraperitoneal injection in 8 groups of mice after 48 h treatment. Then, intraperitoneal injections of LD50 of oxothiazole solution into 4 other mice were done to evaluate histopathological changes in their liver and kidney tissues. The histopathological studies were identified as fatty change, hepatitis, necrosis and regeneration in liver, and fibrosis, necrosis, nephritis, hyaline cast and hyperaemia in kidney. In conclusion, the synthesized oxothiazole derivative causes renal and hepatic toxicity in mice at medium concentrations. The change of thiazole substituents and complexation may reduce its toxicity.

کلیدواژه‌ها

Toxic effect؛ Histopathological study؛ Oxothiazole derivative

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