The Association between erythropoietin, vitamin D3 and parathormone levels and kidney lesions in buffaloes (Bubalus bubalis)

Iranian Journal of Veterinary Science and Technology

مقاله 4، دوره 12، شماره 1 - شماره پیاپی 22، شهریور 2020، صفحه 29-36   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/veterinary.v12i1.85313

نویسندگان

Zana Shahabi¹؛ Mohammad Razi Jalali^{* 2}؛ Babak Mohamadian²؛ Mohammad Rahim Haji Hajikolaei²؛ Mohammad Taha Jalali³

¹DVSc Student of Clinical Pathology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

²Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

³Faculty of Para Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

چکیده

Many diseases, including renal disorders in ruminants, appear in subclinical form and lead to reduced production without causing clinical signs. In this research, blood and tissue samples of kidney were taken from 102 buffaloes from Ahvaz industrial abattoir and sent to the laboratory for biochemical and histopathological analysis. After preparing the pathological sections from kidney specimens, conventional and specific staining and microscopic examination, 41 samples had no kidney lesion was considered as control and 61 specimens as the lesion group. The samples with renal lesions were divided into 4 subgroups including acute tubulointerstitial nephritis, chronic tubulointerstitial nephritis, Urinary tubular inflammation, and Congestion. The samples were also divided and compared to males and females. In blood samples, serum biochemical tests including parathyroid hormone, erythropoietin, and vitamin D3 were measured by using ELISA-specific commercial kits. After statistical analysis, the results of vitamin D3 in the studied groups did not show any significant difference. However, erythropoietin and parathormone values in buffaloes with renal lesions were significantly lower and higher than those in control animals respectively. The results of this study showed that most of the kidney lesions in the studied buffaloes including the mentioned above have led to a decrease in the production of erythropoietin hormone following the occurrence of these lesions and its functional effects on the kidneys. Naturally, the effects of this hormone deficiency are expected to be reflected in the hemogram and eventually, anemia resulting from it may affect overall body health.

کلیدواژه‌ها

Bubalus bubalis؛ Kidney lesions؛ Erythropoietin؛ Vitamin D3؛ Parathormone

مراجع

1. Owen E, Smith T, Kitalyi A, Jayasuriya N. Livestock and wealth creation-improving the husbandry of animals kept by poor people in developing countries. UK: Natural Resources International Ltd. 2005; Pp: 206-211.

2. Borghese A. Buffalo production and research, 1st edition, FAO of the United Nations, Rome. 2005; 1-5.

3. Baharizade M, Vaez Torshiz R. Evaluation of environmental factors on important production traits of Iranian buffaloes. Animal Science Research, 2011; 21(1): 127-138

4. Ansari-Lari M. Abattoir study of kidney condemnation in food animals in Shiraz, south of Iran (1992-2004), International Journal of Dairy Science, 2007; 2: 100-103.

5. Vegad JL, Swamy MA. Textbook of Veterinary Systemic Pathology. International Book Distributing Co. 2010; Pp: 129-146.

6. Divers TJ, Crowell WA, Duncan JR, Whitlock RH. Acute renal disorders in cattle: A retrospective study of 22 cases. Journal of the American Veterinary Medical Association, 1982; 181(7):694-699.

7. Yeruham I, Elad D, Avidar Y, Goshen, T. A herd level analysis of urinary tract infection in dairy cattle. Veterinary Journal, 2006; 171: 172-176.

8. Gemma O, Jose MMF, Ines M, Anton GM, Maria PRT, Jose MLN, Diego RP. Impaired erythropoietin synthesis in chronic kidney disease is caused by alterations in extracellular matrix composition. Journal of Cellular and Molecular Medicine, 2018; 22(1): 302-314.

9. Erslev AJ, Besarab A. Erythropoietin in the pathogenesis and treatment of the anemia of chronic renal failure. Kidney International, 1997; 51: 622-630.

10. Nelson CD, Lippolis JD, Reinhardt TA, Sacco RE, Powell JL, Drewnoski ME, O’Neil M, Beitz DC, Weiss WP. Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of Dairy Science, 2016; 99:10150–10160.

11. Horst RL, Goff JP, Reinhardt TA, Buxton DR. Strategies for preventing milk fever in dairy cattle. Journal of Dairy Science, 1997; 80: 1269-1280.

12. Horst RL, Goff JP, Reinhardt TA. Calcium and vitamin D metabolism in the dairy cow. Journal of Dairy Science, 1994; 77: 1936-1951.

13. Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N. Erythropoietin synthesis in renal myofibroblasts is restored by activation of hypoxia signaling. Journal of the American Society of Nephrology, 2016; 27: 428-38.

14. Zeisberg M, Bonner G, Maeshima Y, Colorado P, Muller, GA, Strutz F, Kalluri R. Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. American Journal of Pathology, 2001; 159: 1313–1321.

15. Torregrosa JV, Bover J, Cannata J. Spanish Society of Nephrology recommendations for controlling mineral and bone disorders in chronic kidney disease patients (S.E.N.-M.B.D.) Nefrologia, 2011; 31(1): 3-32.

16. Bellorin Font E, Ambrosoni P, Carlini RG, Carvalho AB, Correa Rotter R, Cueto Manzano A. Guias de practica clinica para la prevencion, diagnostico, evaluacion y tratamiento de los trastornos minerales y oseos en la enfermedad renal cronica (TMO-ERC) en adultos. Nefrologia, 2013; 33(1): 1-28.

17. Restrepo VCA, Aguirre AJV. Vitamin D (25(OH) D) in patients with chronic kidney disease stages 2-5. Colombia Medica, 2016; 47(3): 160-166.

18. Nikodimopoulou M, Liakos S. Secondary hyperparathyroidism and target organs in chronic kidney disease. HIPPOKRATIA, 2011; 15(1): 33-38.

19. Newman SJ. Urinary system. In: McGavin MD, Zachary JF, editors. Pathologic Basis of Veterinary Disease. Mosby Elsevier. Missouri. USA. 2012; 589-657.

20. Mohammadian B, Nikvand AA, Haji Hajikolaei MR, Ghadrdan Mashhadi AR, Ghorbanpoor M. Pathological study of urinary bladder and kidney in slaughtered water buffalo (Bubalus bubalis) at ahvaz abattoir. Iranian Veterinary Journal, 2012; 12(3): 69-75.

21. Nikvand AA, Haji Hajikolaei MR, Ghadrdan Mashhadi AR, Ghorbanpour M, Mohammadian B. Bacteriological study of urine and its relationship with histopathological findings of bladder and kidney in river buffalo (Bubalus bubalis). Iranian Journal of Veterinary Medicine, 2014; 8(3): 157-161.

22. Baghban F, Yaripour H. Histopathological lesions of condemned kidneys of sheep and goats slaughtered in Yasuj Abattoir, Iran. Indian Journal of Veterinary Pathology, 2016; 40(4): 356-358.

23. Hatipoglu F, Erer H. Pathological investigations on renal lesions in sheep. Atatürk University Journal of Veterinary Sciences, 2001; 17: 39-50.

24. Mathur M, Dadhich H. Interstitial nephritis in sheep of Rajasthan, Indian Journal of Animal Research, 2005; 39: 151-152.

25. Kojouri GA, Karimi I, Jafarian M, Rasoli Rizi A. Abattoir survey on bovine kidney diseases in Shahrekord district. Pajouhesh & Sazandegi, 2008; 78: 2-7.

26. Monaghan MLM, Hannan J. Abattoir survey of bovine kidney disease. Veterinary Record, 1983; 113: 55-57.

27. Nourmohammadzadeh F, Haji Hajikolaei MR, Sasani, F, Alidadi N. Abattoir study of the prevalence of renal lesions in slaughtered cattle. International Journal of Veterinary Research, 2010; 4(3): 173-175.

28. Taghadosi V, Hosseinzadeh S, Shekarforoush SS, Samiei A. Prevalence of renal lesions in slaughtered cattle in Shiraz, Iran, and detection of Leptospira in them by nested PCR-RFLP. Tropical Animal Health and Production, 2016; 48(8): 1691-1696.