Effects of single injection of vitamin D3 on some immune and oxidative stress characteristics in transition dairy cows

Iranian Journal of Veterinary Science and Technology

مقاله 4، دوره 12، شماره 2 - شماره پیاپی 23، پاییز و زمستان 2020، صفحه 25-35  

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/ijvst.2020.39239

نویسندگان

Morteza Hassanabadi¹؛ Mehrdad Mohri ²؛ Hesam A. Seifi³

¹Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

²Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran &Center of Excellence in Ruminant Abortion and Neonatal Mortality, Ferdowsi University of Mashhad, Mashhad, Iran.

³Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran & Center of Excellence in Ruminant Abortion and Neonatal Mortality, Ferdowsi University of Mashhad, Mashhad, Iran.

چکیده

Recent studies suggest that vitamin D may have preventive and therapeutic effects on autoimmune disease, cancer, and diabetes type 1 and 2 beyond the skeletal condition and calcium metabolism. To demonstrate the effects of an over-supplemented single 8 million I.U. vitamin D3 IM injection on the modulation of immune responses and oxidative/antioxidative variables in transition dairy cows, this study was conducted on a commercial dairy farm with about 1500 lactating cows in the Tehran province, Iran. Twenty-four multiparous Holstein cows were randomly categorized into control and treatment groups. In the treatment group, 12 cows received a single dose of 8,000,000 IU vitamin D intramuscularly. In the control group, a placebo (distilled water) was injected into 12 cows 2 to 8 days before the expected calving time. Blood samples were collected on 21 and 7 days before calving and 1,3,7,15, and 30 days after calving. 25(OH)vitamin D3, tumor necrosis factor- α (TNF-α), interferon-γ (INF-γ), haptoglobin, interleukin 6 (IL-6), ferric reducing the ability of plasma (FRAP), glutathione peroxidase (GPx), superoxide dismutase (SOD), and hemolysate GPx were measured. This study showed that the treatment group had significantly higher amounts of 25(OH) vitamin D3, hemolysate GPx, and IL-6 values than the control group. According to our results, vitamin D3 injection increased the amounts of IL-6 and hemolysate GPx activity and tended to affect serum GPx activity. 

کلیدواژه‌ها

Haptoglobin؛ immune regulation؛ superoxide dismutase؛ 25(OH) Vitamin D

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