Numerical Simulation of Same-sized Cells Focusing and Separation with Surface Acoustic Waves

علوم کاربردی و محاسباتی در مکانیک

Article 5, Volume 32, Issue 1 - Serial Number 23, 2021, Pages 77-92   

Document Type: Original Article

DOI: 10.22067/jacsm.2021.56217.0

Authors

Donya shahani¹; Abas Ramiar^{* 2}; Arash Mahboubidoust¹

¹Mechanical Engineering, Microfluidics and MEMS Lab, Babol Noshirvani University of Technology.

²Microfluidics and MEMS Lab, Babol Noshirvani University of Technology.

Abstract

Detection and analysis of circulating tumor cells can provide important information to prevent the spread of cancer, which annually kills millions of people worldwide. So the researchers are trying to find a way to separate these cancer cells for detecting them. In this study, the OpenFOAM code was used to simulate the sheathless focusing and separation of White Blood Cells from Prostate cancer cells using standing and traveling surface acoustic waves in two stages. In the first stage, cells are focused in the center of the channel utilizing standing waves. Then, with the aid of traveling waves, the white blood cells are pushed to the opposite side and the two cells are separated by 100% efficiency.

Keywords

Acoustophoresis; Traveling Surface Acoustic Waves; Standing Surface Acoustic Waves; Cell Separation; Numerical Simulation; Microfluidic

References

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