Evidence for an interaction between cannabinoidergic and dopaminergic systems with melanocortin MC3/ MC4 receptors in regulating food intake of neonatal chick

Iranian Journal of Veterinary Science and Technology

مقاله 5، دوره 13، شماره 2 - شماره پیاپی 25، اسفند 2021، صفحه 37-45   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijvst.2021.69380.1028

نویسندگان

Mohammad Bameri¹؛ Morteza Zendedel kheybari^{* 2}؛ Bita Vazir¹؛ Ahmad Asghari³؛ Negar Panahi¹

¹Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

²Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

³Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

چکیده

The current study aimed to see how the central dopaminergic and cannabinoidergic mechanisms affect melanocortin-induced food intake in the neonatal layer chickens. In this regard, 9 experiments were designed. In experiment 1, chicks injected with control solution, MTII (2.5, 5, and 10 ng). In experiment 2, control solution, L-DOPA (125 nmol), MTII (10 ng), and L-DOPA + MTII were applied to the birds. Experiments 3-9 were similar to experiment 2, except birds injected with 6-OHDA (150 nmol), SCH23390 (5 nmol), AMI-193 (5 nmol), NGB2904 (6.4 nmol), L-741,742 (6 nmol), SR141716A (6.25 µg), and AM630 (5 µg) instead of L-DOPA. Then, cumulative food intake was recorded at 30, 60, and 120 min following injection. According to the results, in comparison with the control group, dose-dependent hypophagia was observed in 3-h food-deprived neonatal layer chickens following ICV injection of MTII (2.5, 5, and 10 ng) (P<0.05). ICV injection of L-DOPA and SR141716A increased hypophagia induced by MTII in chickens (P<0.05), while 6-OHDA greatly suppressed MTII- induced hypophagia (P<0.05). In addition, SCH23390 and AMI-193 greatly weakened the MTII-induced hypophagia in neonatal layer chickens (P<0.05). However, NGB2904, L-741742 and AM630 had no role on hypophagia induced by MTII (P>0.05). These results demonstrated that melanocortin-induced hypophagia in the neonatal layer chickens is likely mediated by D1, D2, and CB1 receptors.

کلیدواژه‌ها

Dopamine؛ Cannabinoid؛ Melanocortin؛ Food intake؛ Layer chicken

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