مقایسه ماتریس‌های روابط خویشاوندی ژنومی متفاوت در پویش ژنومی وزن‌دهی شده چند جمعیتی

پژوهشهای علوم دامی ایران

مقاله 9، دوره 15، شماره 4 - شماره پیاپی 56، دی 1402، صفحه 585-597   

نوع مقاله: مقاله پژوهشی

شناسه دیجیتال (DOI): 10.22067/ijasr.2023.79619.1108

نویسندگان

سید مصطفی مظلوم؛ محمد مهدی شریعتی^*

گروه علوم دامی، دانشکده کشاورزی، دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

هدف از پژوهش حاضر، انتخاب بهترین ماتریس روابط خویشاوندی ژنومی برای پویش ژنومی چندجمعیتی است. ساختار ژنتیکی جمعیت­ها منحصر به فرد هستند، بنابراین برای تشکیل ماتریس روابط خویشاوندی ژنومی چند جمعیتی از ماتریس روابط خویشاوندی ژنومی بلوک­بندی شده استفاده می‌شود. در این مطالعه، ابتدا دو جمعیت با ساختار ژنتیکی متفاوت شبیه­سازی شدند. سپس ماتریس روابط خویشاوندی ژنومی معمولی (G)، ماتریس روابط خویشاوندی ژنومی بلوک­بندی شده (BG) و ماتریس روابط خویشاوندی ژنومی بلوک­بندی وزن­دهی شده با واریانس ژنوتیپی برآورد شده با بیز B (WBG) برای حیوانات تشکیل شدند و برای مطالعات پویش ژنومی تک مرحله­ای استفاده شدند. علاوه‌بر آن، با روش بیزB پویش ژنومی انجام شد و با پویش‌های ژنومی تک مرحله­ای مقایسه شدند. نتایج پویش ژنومی با استفاده از ماتریس­های روابط خویشاوندی G، BG و WBG نشان داد که به‌طور میانگین به‌ترتیب 14، 16، 21 نشانگر ژنومی مرتبط با QTL‌های صفات شناسایی شدند که واریانس ژنتیکی توجیه شده بالای یک درصد دارند. همچنین با استفاده از روش آماری بیز B تنها دو نشانگر ژنومی با واریانس بالای یک درصد شناسایی شدند. علاوه‌براین، میانگین صحت­های پیش­بینی ارزش اصلاحی ژنومی در لحظه هم­گرایی با استفاده از ماتریس­های G، BG و WBG به‌ترتیب 36/0، 39/0، 43/0 برآورد شدند. نتیجه گیری کلی نشان­داد که استفاده از ماتریس­های روابط خویشاوندی ژنومی BG و WBG می­تواند باعث بهبود پویش ژنومی چندجمعیتی یا چندنژادی شود. 

کلیدواژه‌ها

بیزB؛ پویش ژنومی چند جمعیتی؛ ماتریس روابط خویشاوندی ژنومی بلوکی؛ ماتریس روابط خویشاوندی ژنومی

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