Mohammadi-Ghohaki, Tahoura, Hassanpour, Shahin, Zendedel kheybari, Morteza. (1402). Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice. سامانه مدیریت نشریات علمی, 15(2), 56-66. doi: 10.22067/ijvst.2023.78858.1191
Tahoura Mohammadi-Ghohaki; Shahin Hassanpour; Morteza Zendedel kheybari. "Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice". سامانه مدیریت نشریات علمی, 15, 2, 1402, 56-66. doi: 10.22067/ijvst.2023.78858.1191
Mohammadi-Ghohaki, Tahoura, Hassanpour, Shahin, Zendedel kheybari, Morteza. (1402). 'Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice', سامانه مدیریت نشریات علمی, 15(2), pp. 56-66. doi: 10.22067/ijvst.2023.78858.1191
Mohammadi-Ghohaki, Tahoura, Hassanpour, Shahin, Zendedel kheybari, Morteza. Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice. سامانه مدیریت نشریات علمی, 1402; 15(2): 56-66. doi: 10.22067/ijvst.2023.78858.1191

Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice

Iranian Journal of Veterinary Science and Technology
مقاله 7، دوره 15، شماره 2 - شماره پیاپی 31، تابستان 2023، صفحه 56-66    اصل مقاله (218.45 K)
نوع مقاله: Research Articles
شناسه دیجیتال (DOI): 10.22067/ijvst.2023.78858.1191
نویسندگان
Tahoura Mohammadi-Ghohaki1؛ Shahin Hassanpour* 2؛ Morteza Zendedel kheybari3
1Graduate student, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran.
چکیده
Considering the beneficial effects of Apium graveolens L. (Celery) on the nervous system, this study elucidates the protective effect of CEO on the experimental model of cuprizone-induced MS in male C57BL/6 mice. Frothy mice were allocated into four experimental groups: control, cuprizone (chew pellet containing 0.2 %CPZ), CEO (800 mg/kg), and CPZ+CEO. Animals received treatments based on their groups for 5 weeks. Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on the findings, ambulation score, hind-limb suspension, front limb suspension, and grip strength significantly decreed in the mice treated with CPZ (p < 0.05). Hind limb foot angle, surface rights, and negative geotaxis significantly increased in the animals treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on ambulation score, surface righting, hind limb suspension, grip strength, and negative geotaxis (p < 0.05). Co-administration of CPZ+CEO significantly diminished the adverse effects of CPZ on the number of crosses in the open field test and duration on the rotarod (p < 0.05). Serum MDA activity increased while GPx, SOD, and TAS decreased in the mice treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on serum antioxidant levels (p < 0.05). These results suggested the protective effect of CEO against CPZ-induced MS mediated by its antioxidant activity.
کلیدواژه‌ها
Celery؛ Essential oil؛ Cuprizone؛ Multiple sclerosis؛ Mice
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