اخبار و اعلانات

 آمار

تعداد نشریات51
تعداد شماره‌ها2,028
تعداد مقالات21,117
تعداد مشاهده مقاله47,503,304
تعداد دریافت فایل اصل مقاله20,379,894
Mohammadi-Ghohaki, Tahoura, Hassanpour, Shahin, Zendedel kheybari, Morteza. (1402). Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice. سامانه مدیریت نشریات علمی, 15(2), 56-66. doi: 10.22067/ijvst.2023.78858.1191
Tahoura Mohammadi-Ghohaki; Shahin Hassanpour; Morteza Zendedel kheybari. "Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice". سامانه مدیریت نشریات علمی, 15, 2, 1402, 56-66. doi: 10.22067/ijvst.2023.78858.1191
Mohammadi-Ghohaki, Tahoura, Hassanpour, Shahin, Zendedel kheybari, Morteza. (1402). 'Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice', سامانه مدیریت نشریات علمی, 15(2), pp. 56-66. doi: 10.22067/ijvst.2023.78858.1191
Mohammadi-Ghohaki, Tahoura, Hassanpour, Shahin, Zendedel kheybari, Morteza. Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice. سامانه مدیریت نشریات علمی, 1402; 15(2): 56-66. doi: 10.22067/ijvst.2023.78858.1191

Protective Effect of Celery ( Apium graveolens L. ) Essential Oil on the Experimental Model of Cuprizone-induced Multiple Sclerosis in Male C57BL/6 Mice

Iranian Journal of Veterinary Science and Technology
مقاله 7، دوره 15، شماره 2 - شماره پیاپی 31، شهریور 2023، صفحه 56-66    اصل مقاله (218.45 K)
نوع مقاله: Research Articles
شناسه دیجیتال (DOI): 10.22067/ijvst.2023.78858.1191
نویسندگان
Tahoura Mohammadi-Ghohaki1؛ Shahin Hassanpour* 2؛ Morteza Zendedel kheybari3
1Graduate student, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran.
چکیده
Considering the beneficial effects of Apium graveolens L. (Celery) on the nervous system, this study elucidates the protective effect of CEO on the experimental model of cuprizone-induced MS in male C57BL/6 mice. Frothy mice were allocated into four experimental groups: control, cuprizone (chew pellet containing 0.2 %CPZ), CEO (800 mg/kg), and CPZ+CEO. Animals received treatments based on their groups for 5 weeks. Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on the findings, ambulation score, hind-limb suspension, front limb suspension, and grip strength significantly decreed in the mice treated with CPZ (p < 0.05). Hind limb foot angle, surface rights, and negative geotaxis significantly increased in the animals treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on ambulation score, surface righting, hind limb suspension, grip strength, and negative geotaxis (p < 0.05). Co-administration of CPZ+CEO significantly diminished the adverse effects of CPZ on the number of crosses in the open field test and duration on the rotarod (p < 0.05). Serum MDA activity increased while GPx, SOD, and TAS decreased in the mice treated with CPZ (p < 0.05). Co-administration of CPZ+CEO significantly reduced the adverse effects of CPZ on serum antioxidant levels (p < 0.05). These results suggested the protective effect of CEO against CPZ-induced MS mediated by its antioxidant activity.
کلیدواژه‌ها
Celery؛ Essential oil؛ Cuprizone؛ Multiple sclerosis؛ Mice
سایر فایل های مرتبط با مقاله
مراجع
1.    Ahmadi SA, Kazemi A, Sabahi M, Razipour S, Salehipour A, Ghiasian M, Ghasemi H, Ranjbar A. Probable antioxidant therapy of Saffron Crocin in patients with multiple sclerosis: A randomized controlled trial. Biomedicine. 2020;40(4):516-21.Doi:10.51248/.v40i4.332
2.    McGinley MP, Goldschmidt CH, Rae-Grant AD. Diagnosis and treatment of multiple sclerosis: a review. Jama. 2021 Feb 23;325(8):765-79. Doi:10.1001/jama.2020.26858
3.    Yánez-Ortiz I, Catalán J, Mateo-Otero Y, Dordas-Perpinyà M, Gacem S, Yeste N, Bassols A, Yeste M, Miró J. Extracellular reactive oxygen species (ROS) production in fresh donkey sperm exposed to reductive stress, oxidative stress and NETosis. Antioxidants. 2021 Sep;10(9):1367. Doi:10.3390/antiox10091367 
4.    Zabihi E, Motavallibashi SE, Bamdad K, Pilevaribadi F, Milan HS. The Effect of Hydroalcoholic Extract of Truffle on Estrogen and Progesterone Levels in Experimental Model of Multiple Sclerosis (MS) in Female Rats. Journal of Arak University of Medical Sciences. 2017 Jun 10;20(3):48-56. 
5.    Abu-Taweel GM. Celery ameliorating against neurobehavioral and neurochemical disorders of perinatal lipopolysaccharides exposure in mice offspring. Journal of King Saud University-Science. 2020 Mar 1;32(2):1764-71. Doi: 10.1016/j.jksus.2020.01.014
6.    Hedayati N, Bemani Naeini M, Mohammadinejad A, Mohajeri SA. Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences. Phytotherapy Research. 2019 Dec;33(12):3040-53. Doi:10.1002/ptr.6492
7.    Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-β in a transgenic model of Alzheimer's disease. Journal of Neuroscience. 2010 Jun 16;30(24):8180-9. Doi:10.1523/JNEUROSCI.0340-10.2010
8.    Nguyen AT, Armstrong EA, Yager JY. Neurodevelopmental reflex testing in neonatal rat pups. JoVE (Journal of Visualized Experiments). 2017 Apr 24(122):e55261. Doi:10.3791/55261
9.    Peng Y, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X. L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice. Journal of Alzheimer's Disease. 2012 Jan 1;29(2):379-91. Doi:10.3233/JAD-2011-111577
10.    Chonpathompikunlert P, Boonruamkaew P, Sukketsiri W, Hutamekalin P, Sroyraya M. The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice. BMC Complementary and Alternative Medicine. 2018 Dec;18(1):1-2. Doi:10.1186/s12906-018-2166-0
11.    Tanasawet S, Boonruamkaew P, Sukketsiri W, Chonpathompikunlert P. Anxiolytic and free radical scavenging potential of Chinese celery (Apium graveolens) extract in mice. Asian Pacific Journal of Tropical Biomedicine. 2017 Jan 1;7(1):20-6. Doi:10.1016/j.apjtb.2016.11.003
12.    Torre-Fuentes L, Moreno-Jiménez L, Pytel V, Matías-Guiu JA, Gómez-Pinedo U, Matías-Guiu J. Experimental models of demyelination and remyelination. Neurología (English Edition). 2020 Jan 1;35(1):32-9. Doi: 10.1016/j.nrl.2017.07.002
13.    Burrows DJ, McGown A, Jain SA, De Felice M, Ramesh TM, Sharrack B, Majid A. Animal models of multiple sclerosis: from rodents to zebrafish. Multiple Sclerosis Journal. 2019 Mar;25(3):306-24. Doi:10.1177/1352458518805246
14.    Xu H, Yang HJ, Zhang Y, Clough R, Browning R, Li XM. Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone. Behavioral neuroscience. 2009 Apr;123(2):418. Doi: 10.1037/a0014477
15.    Zhu X, Yao Y, Hu Y, Yang J, Zhang C, He Y, Zhang A, Liu X, Zhang C, Gan G. Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis. Neurobiology of disease. 2021 1;158:105489. Doi:10.1016/j.nbd.2021.105489.
16.    Sanadgol N, Maleki P. Study of the effects of ellagic acid on population and activity of central nervous system neuroglia cells in the cuprizone-induced multiple sclerosis. Journal of Arak University of Medical Sciences. 2018 Dec 10;21(6):34-46. 
17.    Sanadgol N, Golab F, Tashakkor Z, Taki N, Moradi Kouchi S, Mostafaie A, Mehdizadeh M, Abdollahi M, Taghizadeh G, Sharifzadeh M. Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis. Pharmaceutical biology. 2017 Jan 1;55(1):1679-87. Doi:10.1080/13880209.2017.1319867.
18.    Boonruamkaew P, Sukketsiri W, Panichayupakaranant P, Kaewnam W, Tanasawet S, Tipmanee V, Hutamekalin P, Chonpathompikunlert P. Apium graveolens extract influences mood and cognition in healthy mice. Journal of natural medicines. 2017 Jul;71(3):492-505. Doi:10.1007/s11418-017-1077-6.
19.    Ye X, Rong Z, Li Y, Wang X, Cheng B, Cheng Y, Luo H, Ti Y, Huang X, Liu Z, Zhang YW. Protective role of L-3-n-butylphthalide in cognitive function and dysthymic disorders in mouse with chronic epilepsy. Frontiers in pharmacology. 2018 Jul 11;9:734. Doi: 10.3389/fphar.2018.00734
20.    Shahbazi Y. Chemical Composition and in Vitro Antibacterial Effect of Ziziphora clinopodioides Essential Oil. Pharmaceutical Sciences, September 2015, 21, 51-56. Doi:10.15171/PS.2015.17
21.    Minaiyan M, Ghanadian SM, Hossaini M. Protective effect of Apium graveolens L.(Celery) seeds extracts and luteolin on acetic acid-induced colitis in rats. International Journal of Preventive Medicine. 2021;12. Doi:10.15171/PS.2015.17
22.    Shahi SK, Freedman SN, Dahl RA, Karandikar NJ, Mangalam AK. Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system. Scientific reports. 2019 Dec 16;9(1):19194. Doi:10.1038/s41598-019-55713-7
23.    Williams E, Scott JP. The development of social behavior patterns in the mouse, in relation to natural periods. Behaviour. 1953 Jan 1:35-65. Doi: 10.1163/156853954X00031
24.    Feather-Schussler DN, Ferguson TS. A battery of motor tests in a neonatal mouse model of cerebral palsy. Journal of visualized experiments: JoVE. 2016(117). Doi: 10.3791/53569.
25.    Heyser CJ. Assessment of developmental milestones in rodents. Current protocols in neuroscience. 2003 Oct;25(1):8-18. Doi:10.1002/0471142301.ns0818s25
26.    Corti S. Grip strength. Experimental protocols for SMA animal models, TREAT-NMD 2017. 
27.    Venerosi A, Ricceri L, Scattoni ML, Calamandrei G. Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. Environmental Health. 2009 Dec;8(1):1-1. Doi: 10.1186/1476-069X-8-12
28.    Donato F, de Gomes MG, Goes AT, Borges Filho C, Del Fabbro L, Antunes MS, Souza LC, Boeira SP, Jesse CR. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain research bulletin. 2014 May 1;104:19-26. Doi:10.1016/j.brainresbull.2014.03.004
29.    Eltokhi A, Kurpiers B, Pitzer C. Comprehensive characterization of motor and coordination functions in three adolescent wild-type mouse strains. Scientific reports. 2021 Mar 22;11(1):1-2. Doi: 10.1038/s41598-021-85858-3
30.    Bradford MM. A rapid and sensitive method for quantifying microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry. 1976 May 7;72(1-2):248-54. Doi:10.1006/abio.1976.9999 
31.    Elahinia A, Hassanpour S, Asghari A, Khaksar E. Effects of α-pinene exposure during pregnancy on antidepressant-like behavior following delivery in mice. Iranian Journal of Veterinary Medicine. 2022 May 29. Doi:10.22059/ijvm.2022.341647.1005263
32.    Molazem M, Ramezani A, Soroori S, Jafary Giv Z, Shokrpoor S, Geissbuehler U. Feasibility of Using Evidence-Based Virtopsy to Answer the Possible Clinical and Post-Mortem Questions, in Veterinary Practice. Iranian Journal of Veterinary Medicine. 2021 Dec 14. Doi:10.22059/ijvm.2021.331329.1

آمار
تعداد مشاهده مقاله: 1,054
تعداد دریافت فایل اصل مقاله: 627


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب