Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats

Iranian Journal of Veterinary Science and Technology

مقاله 6، دوره 15، شماره 2 - شماره پیاپی 31، شهریور 2023، صفحه 48-55   

نوع مقاله: Research Articles

شناسه دیجیتال (DOI): 10.22067/ijvst.2023.80490.1219

نویسندگان

Abdulfatai Aremu^{* 1}؛ Jiddah Fatimah Idris²؛ Ganiu Jimoh Akorede²؛ Aishat Omobolanle Olatumji²؛ Afisu Basiru³؛ Akeem Olayiwola Ahmed⁴

¹Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.

²Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.

³Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.

⁴Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.

چکیده

Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity. We performed this experiment to compare the analgesic activities of Lawsonia inermis, Waltheria indica, Moringa oleifera, and Nigella sativa in Wistar rats using writhing and paw lick responses. We grouped 21 adult female rats into seven groups (n=3), including uninduced and untreated rats (group 1), induced untreated rats (group 2), rats treated with Lawsonia inermis at 200 mg/kg (group 3), rats treated with Waltheria indica at 200 mg/kg (group 4), rats treated with Nigella sativa at 200 mg/kg (group 5), rats treated with Moringa oleifera at 200 mg/kg (group 6), and rats treated with diclofenac at 10 mg/kg (group 7). We dosed rats for 14 days after inducing the pain. Phytochemical screening showed that methanolic extracts of Lawsonia inermis, Moringa oleifera, and ethanolic extract of Waltheria indica contain: Alkaloid, saponin, steroid, tannin, flavonoid, phenols, terpene, and glycosides. The rate of weight gain in rats treated with M. oleifera and W. indica was 7%, and with diclofenac was 9% compared to the untreated control. L. inermis and N. sativa possessed a weight gain of 3% and 2%, respectively. All the extracts exhibited analgesic activities by significantly reducing the number of lick and writh in the order of Lawsonia inermis, Nigella sativa, Moringa oleifera, and Waltheria indica.This study concluded that Lawsonia inermis possess significant analgesic activities compared to other plants and the standard drug (diclofenac).

کلیدواژه‌ها

Pain؛ Lawsonia inermis؛ Nigella sativa؛ Moringa oleifera؛ Waltheria indica؛ Analgesic

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