Therapeutic Intervention for Caseous Lymphadenitis Using Intra-abscess Instillation of Ozone or Hydrogen Peroxide in Small Ruminants

Iranian Journal of Veterinary Science and Technology

دوره 15، شماره 3 - شماره پیاپی 32، آذر 2023، صفحه 16-26   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijvst.2023.82086.1246

نویسندگان

Gholam Ali Khorshidian¹؛ Ramin Moradi¹؛ Omid Rajabi²؛ Behnaz Norouzi³؛ Mahdi Askari Badouei⁴؛ Kamran Sharifi^{* 5}

¹Department of Clinical Science, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

²Department of Pharmaceutical control, Faculty of pharmacy, Mashhad university of medical sciences, Mashhad, Iran.

³Drs. Norouzi's private veterinary practice, Zirkuh District, South Khorasan province, Iran.

⁴Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

⁵Department of Clinical Science, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

چکیده

CLA is an economically and zoonotically important disease in the world. The lack of a therapeutic procedure limits the treatment mainly to surgical intervention. Therapeutic efficacies of the intra-abscess instillation of O3-oil and H2O2-gly in CLA in small ruminants were tested. One hundred eighty affected sheep and goats were allocated to five groups as follows: 1) NC (no intervention), 2) PC1 (injection of olive oil), 3) PC2 (injection of glycerin), 4) injection of O3-oil, 5) injection of H2O2-gly. Samples of abscess contents were collected for microbiological examination prior to injection. The VAs were measured on T0, then with two-week intervals on T1 and T2. On T0 and T2, VAs were as NC (2.9 ± 0.5; 3.5 ± 0.5), PC1 (3.4 ± 0.7; 6.6 ± 1), PC2 (3.1 ± 0.7; 3.3 ± 0.9), O3-oil (3.3 ± 0.4; 0.4 ± 0.4), and H2O2-gly (4.6 ± 0.4, 1.5 ± 0.4). Statistical analysis showed a significant decrease in VAs, merely in treatment groups. CP was recovered in 48.3% of bacteriological samples. The results of this study suggested that O3-oil and H2O2-gly would be reliable therapeutic agents for treating and controlling CLA. Ozone showed apparently a higher  efficacy and caused more rapid shrinkage/recession of the abscesses, compared to hydrogen peroxide..

کلیدواژه‌ها

Abscess؛ Caseous lymphadenitis؛ Ozone؛ Hydrogen peroxide؛ Small ruminants

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