The Effect of Selected Aerobic Activities and Consumption of Omega-3 Supplementation on Plasma Concentrations of sICAM-1 and sVCAM-1 in Elderly Obese Women

Research in Exercise and Sports Medicine

دوره 4، شماره 1، بهمن 2013، صفحه 57-66   

نوع مقاله: Original Article

چکیده

Purpose: Obesity is considered a growing cause of cardiovascular diseases. The cellular and vascular cell 
adhesion molecules have been identified as the new inflammatory indicators of forecasting and predicting 
cardiovascular diseases. The purpose of this study, therefore, was to investigate the effect of selected aerobic
activities and consumption of omega-3 supplementation on plasma concentrations of sICAM-1 and sVCAM-1
in elderly obese women. 
Material and Methods: In a double-blinded study, 40 obese women (BMI ≥ 30) 55 to 65 years old, were 
selected in a non-random and easily-accessible way and were randomly categorized into 4 groups of 10 
individuals: exercise-placebo, exercise-supplements, supplements, and placebo. Subjects in the supplement 
groups consumed 2080 mg of omega-3 supplement for 8 weeks and placebo groups used sunflower oil
produced in Zachariah Company, as placebo. Exercise program included aerobic exercise activities at 45 to 60 
percent of maximum heart rate for 8 weeks, three 60-minute sessions per week. After 12 h fasting in the pretest and 48 h fasting after the last training session, blood sampling was conducted. Data analysis included 
paired-t test and two-way ANOVA and was carried out using SPSS software (version 16).
Results: The obtained results showed that there was a significant interaction between exercise and
supplements in reducing serum sICAM-1 factor, suggesting that sICAM- 1 reduction was both influenced by 
the separate effects of supplements and exercise, and the combined intervention of both exercise and
supplements which had a synergistic effect on reducing the concentrations of this inflammatory factor. In 
addition, serum sVCAM-1 decreased significantly only in the exercise-supplement group (combined) (P < 
0.05).
Discussion and Conclusion: The results indicated that considering sensitivity and accuracy of new 
inflammatory indices, measuring these indicators could be useful in the diagnosis of inflammation and vascular 
disorders. Besides, regular aerobic exercise and omega-3 supplements are two effective and moderating
factors reducing the level of adhesion molecules (sICAM-1 and sVCAM-1) and inflammation.

کلیدواژه‌ها

sICAM-1؛ sVCAM-1؛ Cardiovascular diseases؛ Omega-3؛ Elderly women