Purpose: Fenugreek, as an herbal plant, can significantly increase Apo A-I, an important factor in preventing cardio vascular diseases among diabetic patients, which is a major cause of their mortality. Considering that exercise activities have a positive effect on diabetic patients, this study aimed to investigate the effects of 6 weeks of aerobic training and fenugreek administration on Apo A-I levels of diabetic women. Material and Methods: Thirty diabetic women volunteered to take part in the present study and were randomly placed into three groups: aerobic training (Group 1), aerobic training+ fenugreek administration (Group 2) and control group (Group 3). Aerobic training group exercised for 6 weeks, at 60-75 %of their maximal heart rate. Blood sampling was done before and after the trial. Results: There was a significant decrease in weight, body fat percent, BMI and fasting blood sugar, and a significant increase in Apo A-I, HDL and HDL/LDL ratio (p<0.001) in the groups 1,2. A significant decrease was also observed in TG levels of group 1. Increased level of LDL was the only significant change observed in the control group. Total cholesterol and HDL/LDL ratio of group 2 decreased and increased, respectively, as compared to group 1 (p<0.05). Discussion and Conclusion: Fenugreek extract along with aerobic training can be useful in increasing levels of Apo A-I and lowering LDL levels in diabetic patients |