Drug release from a two-layer stent coating considering the viscoelastic property of the arterial wall: A mathematical and numerical study

Iranian Journal of Numerical Analysis and Optimization

مقاله 7، دوره 14، Issue 2 - شماره پیاپی 29، شهریور 2024، صفحه 475-499   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijnao.2024.85218.1335

نویسندگان

E. Azhdari^* ؛ A. Emami

Department of Mathematics, Salman Farsi University of Kazerun, Iran.

چکیده

Atherosclerosis is one of the most common diseases in the world. Med-ication with metal stents plays an important role in treating this disease. There are many models for delivering drugs from stents to the arterial wall. This paper presents a model that describes drug delivery from the stent coating layers to the arterial wall tissue. This model complements the previous models by considering the mec hanical properties of the arte-rial wall tissue, which changes due to atherosclerosis and improves results for designing stents. The stability behavior of the model is analyzed, and a number of numerical results are provided with explanations. A compar-ison between numerical and experimental results, which examine a more accurate match between the in vivo and in vitro, is shown.

کلیدواژه‌ها

Stent coating؛ Viscoelastic؛ Mathematical model؛ Numerical simulation

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