ایجاد پوشش دولایه‏ nHydroxyapatite/Poly(lactic-co-glycolic)acid بر منیزیم و بررسی خواص خوردگی و زیست‎‏سازگاری

مهندسی متالورژی و مواد

مقاله 3، دوره 35، شماره 3 - شماره پیاپی 35، مهر 1403، صفحه 35-50   

نوع مقاله: علمی و پژوهشی

شناسه دیجیتال (DOI): 10.22067/jmme.2024.83920.1121

نویسندگان

ندا عبودزاده^* ؛ مینا محمدی زاده؛ علیرضا خاوندی؛ علیرضا ایوانی

دانشکده مهندسی مواد و متالورژی، دانشگاه علم و صنعت ایران، تهران، ایران

چکیده

در این تحقیق با هدف کنترل خوردگی و امکان کاربرد کلینیکی منیزیم، پوشش دولایه هیدروکسی ‏آپاتیت -پلی ‏لاکتیک‏ گلیکو لیک ‏اسید به ترتیب با روش‌های رسوب دهی الکتریکی و غوطه وری بر نمونه منیزیمی اعمال گردید. مشخصه ‏یابی پوشش‌ها با کمک پراش پرتو ایکس و میکروسکوپ الکترونی روبشی، نشان دهنده تشکیل یکنواخت پوشش ها با ضخامت µm 30 – 20 بر سطح منیزیم است. آزمون‏ الکتروشیمیایی پلاریزاسیون تافل بر نمونه‌ها نشان داد که با اعمال پوشش دو لایه هیدروکسی ‏آپاتیت- پلی ‏لاکتیک ‏گلایکولیک ‏اسید بر منیزیم، پتانسیل خوردگی از V 82/1- به V 4/1- افزایش و چگالی جریان خوردگی از µA/cm2 3/2 به µA/cm2 37/0 کاهش می‏ یابد. نتایج آزمون MTT نیز نشان داد که مقدار تکثیر سلولی در مجاورت عصاره 48 ساعته نمونه‏ های منیزیمی با پوشش دو لایه بیشتر شده است، که حکایت از کاهش مقدار یون آزاد شده از سطح منیزیم با کمک اعمال این پوشش ها است.

کلیدواژه‌ها

منیزیم؛ هیدروکسی&rlm؛ آپاتیت؛ پلی&rlm؛ لاکتیک&rlm؛ گلایکولیک&rlm؛ اسید؛ زیست&rlm؛ سازگاری؛ خوردگی

مراجع

[1]    J. Chen, Y. Yang, I. P. Etim, L. Tan, K. Yang, R. D. K. Misra, J. Wang, and X. Su, " Recent advances on development of hydroxyapatite coating on biodegradable magnesium alloys: a review", Materials, vol. 14, no. 19, pp. 5550, 2021.  https://doi.org/10.3390/ma14195550

[2]    L. Ling, S. Cai, Q. Li, J. Sun, X. Bao, and G. Xu, "Recent advances in hydrothermal modification of calcium phosphorus coating on magnesium alloy", Journal of Magnesium and Alloys, vol. 10, no. 1, pp. 62-80, 2021. https://doi.org/10.1016/j.jma.2021.05.014

[3]    V. Yadav, M. Sankar, and L. Pandey, "Coating of bioactive glass on magnesium alloys to improve its degradation behavior: Interfacial aspects", Journal of Magnesium and Alloys, vol. 8, no. 4, pp. 999-1051, 2020.https://doi.org/10.1016/j.jma.2020.05.005

[4]    R. Karunakaran, S. Ortgies, A. Tamayol, F. Bobaru, and M. P. Sealy, "Additive manufacturing of magnesium alloys", Bioactive Materials, vol. 5, no. 1, pp. 44-54, 2020. https://doi.org/10.1016/j.bioactmat.2019.12.004

[5]    B. R. Sunil, T. S. Kumar, U. Chakkingal, V. Nandakumar, M. Doble, V. Devi Prasad, and M. Raghunath, "In vitro and in vivo studies of biodegradable fine grained AZ31 magnesium alloy produced by equal channel angular pressing", Materials Science and Engineering: C, vol. 59, pp. 356-367, 2016. https://doi.org/10.1016/j.msec.2015.10.028

[6]    G. Song, "Control of biodegradation of biocompatable magnesium alloys", Corrosion Science, vol. 49, no. 4, pp. 1696-1701, 2007. https://doi.org/10.1016/j.corsci.2007.01.001

[7]    C. Blawert, W. Dietzel, E. Ghali, and G. Song, "Anodizing treatments for magnesium alloys and their effect on corrosion resistance in various environments", Advanced Engineering Materials, vol. 8, no. 6, pp. 511-533, 2006. https://doi.org/10.1002/adem.200500257

[8]    C. Wen, X. Zhan, X. Huang, F. Xu, L. Luo, and C. Xia, "Characterization and corrosion properties of hydroxyapatite/graphene oxide bio-composite coating on magnesium alloy by one-step micro-arc oxidation method", Surface and Coatings Technology, vol. 317, pp. 121-133, 2017. https://doi.org/10.1016/j.surfcoat.2017.03.034

[9]    H. Amiri, I. Mohammadi, and A. Afshar, "Electrophoretic deposition of nano-zirconia coating on AZ91D magnesium alloy for bio-corrosion control purposes", Surface and Coatings Technology, vol. 311, pp. 182-190, 2017. https://doi.org/10.1016/j.surfcoat.2016.12.103

[10] W. Liu, Z. Yan, Z. Zhang, Y. Zhang, G. Cai, and Z. Li, "Bioactive and anti-corrosive bio-MOF-1 coating on magnesium alloy for bone repair application", Journal of Alloys and Compounds, vol.788, pp. 705-711, 2019. https://doi.org/10.1016/j.jallcom.2019.02.281

[11] M. Razavi, M. Fathi, O. Savabi, S. M Razavi, B. H. Beni, D. Vashaee, and L. Tayebi, "Controlling the degradation rate of bioactive magnesium implants by electrophoretic deposition of akermanite coating", Ceramics International, vol. 40, no. 3, pp. 3865-3872, 2014. https://doi.org/10.1016/j.ceramint.2013.08.027

[12] H. Wang, C. Zhao, Y. Chen, J. Li, and X. Zhang, "Electrochemical property and in vitro degradation of DCPD–PCL composite coating on the biodegradable Mg–Zn alloy", Materials Letters, vol. 68, pp. 435-438, 2012. https://doi.org/10.1016/j.matlet.2011.11.029

[13] M. Tomozawa, S. Hiromoto, and Y. Harada, "Microstructure of hydroxyapatite-coated magnesium prepared in aqueous solution", Surface and Coatings Technology, vol. 204, no. 20, pp. 3243-3247, 2010.  https://doi.org/10.1016/j.surfcoat.2010.03.023

[14] A. Saberi, H.R. Bakhsheshi-Rad, S. Abazari, A.F. Ismail, S. Sharif, S. Ramakrishna, M. Daroonparvar, and F. Berto, "A comprehensive review on surface modifications of biodegradable magnesium-based implant alloy: Polymer coatings opportunities and challenges", Coatings, vol. 11, no. 7, pp. 747, 2021. https://doi.org/10.3390/coatings11070747

[15] S. M. Kim, M. H. Kang, H. E. Kim, H. K. Lim, S. H. Byun, J. H. Lee, and S. M. Lee, "Innovative micro-textured hydroxyapatite and poly (l-lactic)-acid polymer composite film as a flexible, corrosion resistant, biocompatible, and bioactive coating for Mg implants" , Materials Science and Engineering: C, vol. 81, pp. 97-103, 2017. https://doi.org/10.1016/j.msec.2017.07.026

[16] Y. F. Zheng, X. N. Gu, and F. Witte, "Biodegradable metals", Materials Science and Engineering: R: Reports, vol. 77, pp. 1-34, 2014. https://doi.org/10.1016/j.mser.2014.01.001

[17] L. Xu, and A. Yamamoto, "Characteristics and cytocompatibility of biodegradable polymer film on magnesium by spin coating", Colloids and Surfaces B: Biointerfaces, vol. 93, pp. 67-74, 2012. https://doi.org/10.1016/j.colsurfb.2011.12.009

[18] M. Diez, M. H. Kang, S. M. Kim, H. E. Kim, and J. Song, "Hydroxyapatite (HA)/poly-L-lactic acid (PLLA) dual coating on magnesium alloy under deformation for biomedical applications", Journal of Materials Science: Materials in Medicine, vol. 27, no. 34, 2016. https://doi.org/10.1007/s10856-015-5643-8

[19] H. Bakhsheshi-Rad, E. Hamzah, M. Abdul-Kadir, S. N. Saud, M. Kasiri-Asgarani, and R. Ebrahimi-Kahrizsangi, "The mechanical properties and corrosion behavior of double-layered nano hydroxyapatite-polymer coating on Mg-Ca alloy", Journal of Materials Engineering and Performance, vol. 24, pp. 4010-4021, 2015. https://doi.org/10.1007/s11665-015-1661-4

[20] M. S. Safavi, F. C. Walsh, M. A. Surmeneva, R. A. Surmenev, and J. Khalil-Allafi, "Electrodeposited hydroxyapatite-based biocoatings: Recent progress and future challenges", Coatings, vol. 11, no. 1, pp. 110, 2021.  https://doi.org/10.3390/coatings11010110

[21] D. Gopi, J. Indira, and L. Kavitha, "A comparative study on the direct and pulsed current electrodeposition of hydroxyapatite coatings on surgical grade stainless steel", Surface and Coatings Technology, vol. 206, no. 11-12, pp. 2859-2869, 2012. https://doi.org/10.1016/j.surfcoat.2011.12.011

[22] J. H. Park, Y. K. Lee, K. M. Kim, and K. N. Kim, "Bioactive calcium phosphate coating prepared on H2O2-treated titanium substrate by electrodeposition", Surface and Coatings Technology, vol. 195, no. 2-3, pp. 252-257, 2005. https://doi.org/10.1016/j.surfcoat.2004.08.185

[23] H. Bakhsheshi-Rad, E. Hamzah, A. Ismail, M. Aziz, M. Kasiri-Asgarani, E. Akbari, S. Jabbarzare, A. Najafinezhad, and Z. Hadisi, "Synthesis of a novel nanostructured zinc oxide/baghdadite coating on Mg alloy for biomedical application: In-vitro degradation behavior and antibacterial activities", Ceramics International, vol. 43, no. 17, pp. 14842-14850, 2017. https://doi.org/10.1016/j.ceramint.2017.07.233

[24] X. Gu, W. Zheng, Y. Cheng, and Y. F. Zheng, "A study on alkaline heat treated Mg–Ca alloy for the control of the biocorrosion rate", Acta Biomaterialia, vol. 5, no. 7, pp. 2790-2799, 2009. https://doi.org/10.1016/j.actbio.2009.01.048

[25] A. Nikbakht, C. Dehghanian, and R. Parichehr, "Silane coatings modified with hydroxyapatite nanoparticles to enhance the biocompatibility and corrosion resistance of a magnesium alloy", RSC Advances, vol. 11, no. 42, pp. 26127-26144, 2021. https://doi.org/10.1039/D1RA01018B

[26] L. Xu, F. Pan, G. Yu, L. Yang, E. Zhang, and K. Yang, "In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy", Biomaterials, vol. 30, no. 8, pp. 1512-1523, 2009. https://doi.org/10.1016/j.biomaterials.2008.12.001

[27] M. Rahman, N. K Dutta, and N. R. Choudhury, "Magnesium alloys with tunable interfaces as bone implant materials", Frontiers in Bioengineering and Biotechnology, vol. 8, 2020. https://doi.org/10.3389/fbioe.2020.00564