Cimetidine-induced Male Reproductive Defects in Piroxicam-induced Gastric Ulcerated Wistar Rats and Their Amelioration by Melatonin

Iranian Journal of Veterinary Science and Technology

دوره 17، شماره 1 - شماره پیاپی 38، خرداد 2025، صفحه 64-74   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijvst.2025.90142.1432

نویسندگان

Afisu Basiru^{* 1}؛ Oluwatobi Chukwuebuka Adetunji¹؛ Ganiu Jimoh Akorede¹؛ Abdulfatai Aremu¹؛ Abdullahi Olaide Ishola²؛ Aishat Omobolanle Olatunji¹

¹Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ilorin, Nigeria.

²Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ilorin, Nigeria.

چکیده

Cimetidine is a known reproductive toxicant due to its adverse effects on testicular function. Melatonin is an antioxidant that has a role in mitigating any disorders that could affect spermatogenesis. Therefore, this study evaluated the ameliorative potential of melatonin on the adverse reproductive effects of cimetidine in piroxicam-induced gastric ulcerated male rats. Thirty rats were randomly divided into six groups (n=5), including normal control (distilled water), ulcerated and non-treated, ulcerated and treated with cimetidine (200mg/kg day), ulcerated and treated with cimetidine and melatonin (10mg/kg), treated with cimetidine and melatonin without ulceration, and ulcerated rats treated with only melatonin. All treatments were done orally per day for 14 days. On the 15th day, rats were sacrificed, and blood samples were collected for hormone and antioxidant assays. Then, the sperm parameters were analyzed according to standard procedures. Co-administration of melatonin to piroxicam-ulcerated rats treated with cimetidine showed a significant increase (p < 0.05) in sperm count and epididymal glutathione peroxidase compared to piroxicam-ulcerated rats treated with only cimetidine. Melatonin increases the serum level of Testosterone, FSH, and LH.  Melatonin ameliorates the adverse reproductive effects of cimetidine through its antioxidant properties. Therefore, co-administration of melatonin with cimetidine in male ulcer patients is recommended.

کلیدواژه‌ها

Antioxidants؛ Cimetidine؛ Gastric ulcer؛ Melatonin؛ Sperm parameters

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