Preventive effects of silymarin on diclofenac-induced toxicity in the domestic pigeon

Iranian Journal of Veterinary Science and Technology

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 22 مرداد 1403   

نوع مقاله: Research Article

شناسه دیجیتال (DOI): 10.22067/ijvst.2024.87040.1356

نویسندگان

nasser vajdi^{* 1}؛ Saeed Seifi²؛ Shohreh Alian Samakkhah³

¹Department of clinical sciences, Faculty of veterinary medicine, Amol university of special modern technologies , Amol , Iran.

²Department of Clinical Sciences, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.

³c Department of Food Hygiene, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.

چکیده

This study aimed to evaluate the effects of silymarin on diclofenac-induced acute liver and kidney toxicity in domestic pigeons (Columba livia). The use of nonsteroidal anti-inflammatory drugs leads to adverse drug effects such as cardiovascular and gastrointestinal hemorrhage, as well as kidney damage.
The vast number of pharmacological attributes possessed by silymarin describes the remarkable content of research aimed at understanding its effect in the treatment of diverse diseases.
Fifteen pigeons were randomly assigned into 3 groups (1, 2, and 3). Group 1 pigeons served as the negative control group and only were given tap water. Groups 2 and 3 were administered diclofenac (15 milligram/kilogram PO q12h) at the onset of the study, hour 0 until 24 hours. The third group of pigeons was moreover treated with silymarin (35 milligram/kilogram), beginning at 12 hours after diclofenac administration, with the silymarin treatment continuing q12h for 48 hours.
Blood samples were taken from the birds at time 0, 12, 24, and 48 of the experiment for serum biochemistry analysis. The results indicated that treatment of pigeons with silymarin reduced the serum level of aspartate aminotransferase, alanine transaminase, Uric acid, and Urea and relatively increased albumin and total protein.
Clinical observations also indicated the presence of intoxication symptoms such as loss of appetite, diarrhea, and lethargy, which improved more rapidly in the silymarin group. It can be concluded that silymarin reduces acute liver and kidney damage caused by diclofenac in pigeons.

کلیدواژه‌ها

Diclofenac؛ domestic pigeon؛ serum biochemistry؛ silymarin