Identification and study of effective Genes in Feline infectious peritonitis and drug repurposing using systems biology approach

Iranian Journal of Veterinary Science and Technology

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 31 مرداد 1403   

نوع مقاله: Short communication

شناسه دیجیتال (DOI): 10.22067/ijvst.2024.82835.1270

نویسندگان

Mohammad Ahmadi Ashtiyani¹؛ jalal shayegh¹؛ Ali Rezapour²؛ Habib MotieGhader^{* 3}

¹Department of Veterinary medicine, Faculty of Veterinary & Agriculture science, Shabestar Branch, Islamic Azad University, Shabestar, Iran.

²Department of Animal science, faculty of Agriculture, Tabriz Branch, Islamic Azad University, Tabriz, Iran

³Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

چکیده

Feline Infectious peritonitis (FIP) is a systemic infectious disease of cats of viral origin in the coronavirus. The lack of clear signs of the virus before the clinical form of the disease, as well as the lack of easy and inexpensive diagnostic tests that can confirm the definite existence of the virus are other problems in controlling and preventing the spread of the virus. On the other hand, this disease has not yet had an approved drug and treatment protocol. In this paper, at first, the gene co-expression network was reconstructed and modulated by String database and Cytoscape software. The gene ontology and pathways of the modules were obtained by DAVID and KEGG databases. The most important possible pathways are: Proteasome, Protein processing in endoplasmic reticulum, Protein export, Aminoacyl-tRNA biosynthesis, Phagosome, Tuberculosis and T cell receptor signaling pathway. In the other part of the study, the gene-drug network regeneration strategy was used to identify a potential drug that was reconstructed using the DGIdb database and Cytoscape software using the drug gene network. BORTEZOMIB, CARFILZOMIB, OPROZOMIB, IXAZOMIB CITRATE, MARIZOMIB, BCG VACCINE, IC14, NELFINAVIR, RITONAVIR, are some of our recommended drugs for this disease. Although our computational strategy predicting repurposable candidate drugs against FIP disease. However, more detailed experimental trials as well as clinical analysis of drug performance, drug toxicity, and experimental validation are necessary to achieve an accurate and improved treatment protocol.

کلیدواژه‌ها

Feline infectious peritonitis؛ Systems biology؛ Gene co-expression؛ Bioinformatics؛ Coronaviridae